The article "Advancing biomaterials of human origin for tissue engineering" by Fa-Ming Chen and Xiaohua Liu discusses the role of biomaterials in tissue engineering and regenerative medicine. Biomaterials, which can be synthetic or naturally derived, play a crucial role in facilitating tissue regeneration by providing a supportive environment for cells to grow and differentiate. The authors highlight the importance of mimicking the natural extracellular matrix (ECM) to enhance the regenerative potential of tissues and organs. They emphasize the need for biomaterials to be not only effective and safe but also cost-effective and convenient for clinical translation. The article reviews the advancements in the field, including the use of decellularized ECM scaffolds, growth factors, and stem cell-rich preparations derived from human sources. It also discusses the challenges and future directions in the development of human-derived biomaterials, such as the variability in production and potential immune responses. The authors call for a multidisciplinary approach involving clinicians, scientists, and funding agencies to accelerate the development of these biomaterials and their clinical applications.The article "Advancing biomaterials of human origin for tissue engineering" by Fa-Ming Chen and Xiaohua Liu discusses the role of biomaterials in tissue engineering and regenerative medicine. Biomaterials, which can be synthetic or naturally derived, play a crucial role in facilitating tissue regeneration by providing a supportive environment for cells to grow and differentiate. The authors highlight the importance of mimicking the natural extracellular matrix (ECM) to enhance the regenerative potential of tissues and organs. They emphasize the need for biomaterials to be not only effective and safe but also cost-effective and convenient for clinical translation. The article reviews the advancements in the field, including the use of decellularized ECM scaffolds, growth factors, and stem cell-rich preparations derived from human sources. It also discusses the challenges and future directions in the development of human-derived biomaterials, such as the variability in production and potential immune responses. The authors call for a multidisciplinary approach involving clinicians, scientists, and funding agencies to accelerate the development of these biomaterials and their clinical applications.