The paper aims to advance the Resource Nexus concept for research and practice by testing its validity and proposing a robust yet flexible approach. The Resource Nexus considers the management and use of natural resources from an integrated systems perspective, contributing to achieving the Sustainable Development Goals (SDGs) by examining interlinkages with resource security, biodiversity protection, and climate change mitigation and adaptation. The authors conducted a systematic review of 62 nexus-related review papers and consulted with about 60 experts to propose a comprehensive understanding of the Resource Nexus. The paper outlines three main parts: defining the nexus concept, identifying environmental resources covered in the Resource Nexus, and mapping the environmental resources using a typology of components and drivers. The Resource Nexus approach is characterized by its ability to promote cooperation, collaboration, and coordination across different sectors and institutions, addressing temporal and spatial dynamics, and balancing trade-offs between resource management goals. The paper also discusses the gaps and challenges in understanding the nexus, including conceptual, operational, scale-related, governance, and contextual issues. Finally, it explores factors enabling and hindering the implementation of the Resource Nexus, emphasizing the importance of problem setting, research communication, and implementation. The paper concludes with a discussion on nexus frameworks and approaches, tools, and disciplinary modes, highlighting the need for systems thinking and transdisciplinary research to address the complex interlinkages between environmental resources.The paper aims to advance the Resource Nexus concept for research and practice by testing its validity and proposing a robust yet flexible approach. The Resource Nexus considers the management and use of natural resources from an integrated systems perspective, contributing to achieving the Sustainable Development Goals (SDGs) by examining interlinkages with resource security, biodiversity protection, and climate change mitigation and adaptation. The authors conducted a systematic review of 62 nexus-related review papers and consulted with about 60 experts to propose a comprehensive understanding of the Resource Nexus. The paper outlines three main parts: defining the nexus concept, identifying environmental resources covered in the Resource Nexus, and mapping the environmental resources using a typology of components and drivers. The Resource Nexus approach is characterized by its ability to promote cooperation, collaboration, and coordination across different sectors and institutions, addressing temporal and spatial dynamics, and balancing trade-offs between resource management goals. The paper also discusses the gaps and challenges in understanding the nexus, including conceptual, operational, scale-related, governance, and contextual issues. Finally, it explores factors enabling and hindering the implementation of the Resource Nexus, emphasizing the importance of problem setting, research communication, and implementation. The paper concludes with a discussion on nexus frameworks and approaches, tools, and disciplinary modes, highlighting the need for systems thinking and transdisciplinary research to address the complex interlinkages between environmental resources.