Circadian misalignment, where sleep and eating patterns are out of sync with the body's internal clock, is linked to increased risks of obesity, diabetes, and cardiovascular disease. A study involving ten adults who followed a 10-day protocol with a 28-hour "day" showed that misalignment led to lower leptin, higher glucose and insulin, increased blood pressure, and reduced sleep efficiency. These changes were most pronounced when the behavioral cycle was about 12 hours out of phase with the circadian cycle. The study found that misalignment caused three out of eight subjects to exhibit postprandial glucose responses typical of prediabetes. The findings suggest that circadian misalignment, as seen in shift work and jet lag, has significant adverse effects on metabolism and cardiovascular health. The study highlights the importance of aligning daily activities with the body's natural rhythms to maintain metabolic and cardiovascular health. The research underscores the need for further investigation into the mechanisms behind these effects and potential interventions to mitigate the risks associated with circadian misalignment.Circadian misalignment, where sleep and eating patterns are out of sync with the body's internal clock, is linked to increased risks of obesity, diabetes, and cardiovascular disease. A study involving ten adults who followed a 10-day protocol with a 28-hour "day" showed that misalignment led to lower leptin, higher glucose and insulin, increased blood pressure, and reduced sleep efficiency. These changes were most pronounced when the behavioral cycle was about 12 hours out of phase with the circadian cycle. The study found that misalignment caused three out of eight subjects to exhibit postprandial glucose responses typical of prediabetes. The findings suggest that circadian misalignment, as seen in shift work and jet lag, has significant adverse effects on metabolism and cardiovascular health. The study highlights the importance of aligning daily activities with the body's natural rhythms to maintain metabolic and cardiovascular health. The research underscores the need for further investigation into the mechanisms behind these effects and potential interventions to mitigate the risks associated with circadian misalignment.