The article reviews the role of aerobic glycolysis in cell proliferation, highlighting its importance in supporting anabolic reactions and biomass accumulation. Despite the inefficiency of glycolysis in ATP production compared to oxidative phosphorylation, it plays a crucial role in maintaining high levels of glycolytic intermediates necessary for macromolecular synthesis. The authors argue that the primary function of aerobic glycolysis is to provide carbon skeletons for the synthesis of nucleotides, amino acids, lipids, and proteins, which are essential for cell division. They also discuss the regulatory mechanisms that control glycolysis, including the role of signaling pathways such as PI3K/Akt and HIF-1, and the importance of glutamine in anaplerosis and ATP production. The article concludes by emphasizing that the advantages of aerobic glycolysis extend beyond ATP generation, making it a selective advantage for proliferating cells.The article reviews the role of aerobic glycolysis in cell proliferation, highlighting its importance in supporting anabolic reactions and biomass accumulation. Despite the inefficiency of glycolysis in ATP production compared to oxidative phosphorylation, it plays a crucial role in maintaining high levels of glycolytic intermediates necessary for macromolecular synthesis. The authors argue that the primary function of aerobic glycolysis is to provide carbon skeletons for the synthesis of nucleotides, amino acids, lipids, and proteins, which are essential for cell division. They also discuss the regulatory mechanisms that control glycolysis, including the role of signaling pathways such as PI3K/Akt and HIF-1, and the importance of glutamine in anaplerosis and ATP production. The article concludes by emphasizing that the advantages of aerobic glycolysis extend beyond ATP generation, making it a selective advantage for proliferating cells.