This study, conducted by the Medical Research Council Cognitive Function and Ageing Study, aimed to investigate the relationship between neuropathological features of Alzheimer's disease and dementia across different age groups. The researchers assessed 456 brains from individuals aged 69 to 103 years, using a standard neuropathological protocol. They found that the association between neocortical neuritic plaques and dementia was stronger at 75 years of age compared to 95 years of age. In contrast, neocortical cerebral atrophy maintained a strong relationship with dementia at both ages. The study concluded that the association between pathological features of Alzheimer's disease and dementia is stronger in younger old persons than in older old persons, emphasizing the need to consider age when assessing the impact of interventions against dementia on the population.This study, conducted by the Medical Research Council Cognitive Function and Ageing Study, aimed to investigate the relationship between neuropathological features of Alzheimer's disease and dementia across different age groups. The researchers assessed 456 brains from individuals aged 69 to 103 years, using a standard neuropathological protocol. They found that the association between neocortical neuritic plaques and dementia was stronger at 75 years of age compared to 95 years of age. In contrast, neocortical cerebral atrophy maintained a strong relationship with dementia at both ages. The study concluded that the association between pathological features of Alzheimer's disease and dementia is stronger in younger old persons than in older old persons, emphasizing the need to consider age when assessing the impact of interventions against dementia on the population.