The article discusses the role of cytokine dysregulation in the remodeling of the immune system at older ages, a condition known as "inflamm-aging." This condition is characterized by a progressive shift towards a pro-inflammatory phenotype, which is associated with various age-related diseases such as atherosclerosis, diabetes, Alzheimer's disease, rheumatoid arthritis, cancer, and aging itself. The authors highlight several molecular pathways that contribute to this dysregulation, including redox balance changes, the increase in senescent cells, the senescence-associated secretory phenotype (SASP), and the decline in autophagy. They also explore the potential for delaying age-related diseases and aging by suppressing pro-inflammatory mechanisms or improving the resolution of inflammation. The article further discusses the importance of lifestyle factors, such as the Mediterranean diet, in mitigating inflammation and age-related diseases. Additionally, it delves into the mechanisms of inflammation resolution, the role of specialized pro-resolving mediators (SPMs), and the impact of senescent cells on the immune system. The authors emphasize the need for further research to understand and potentially target these molecular pathways to improve the quality of aging and manage age-related degenerative diseases.The article discusses the role of cytokine dysregulation in the remodeling of the immune system at older ages, a condition known as "inflamm-aging." This condition is characterized by a progressive shift towards a pro-inflammatory phenotype, which is associated with various age-related diseases such as atherosclerosis, diabetes, Alzheimer's disease, rheumatoid arthritis, cancer, and aging itself. The authors highlight several molecular pathways that contribute to this dysregulation, including redox balance changes, the increase in senescent cells, the senescence-associated secretory phenotype (SASP), and the decline in autophagy. They also explore the potential for delaying age-related diseases and aging by suppressing pro-inflammatory mechanisms or improving the resolution of inflammation. The article further discusses the importance of lifestyle factors, such as the Mediterranean diet, in mitigating inflammation and age-related diseases. Additionally, it delves into the mechanisms of inflammation resolution, the role of specialized pro-resolving mediators (SPMs), and the impact of senescent cells on the immune system. The authors emphasize the need for further research to understand and potentially target these molecular pathways to improve the quality of aging and manage age-related degenerative diseases.