The article discusses the development and future directions of soft multifunctional sensors in the context of flexible electronics. These sensors are essential components of next-generation flexible electronics and have gained significant research interest due to their ability to detect multiple stimuli, such as strain, pressure, vibration, temperature, humidity, and biochemical markers. The review highlights key characteristics of these sensors, including their flexibility and multifunctionality, and emphasizes the importance of selecting appropriate materials and structures to meet specific application requirements. The article also discusses emerging materials and structures, such as carbon-based materials and MXene-based materials, which offer unique advantages in terms of electrical conductivity, mechanical strength, and sensitivity. The review outlines future research directions, including the decoupling of multiple stimuli, data processing, skin conformability, and energy sources. It also addresses challenges and opportunities for these sensors in the coming decade, emphasizing the need for further advancements in materials, manufacturing techniques, and sensor design to enhance their performance and practicality. The article concludes by emphasizing the importance of balancing performance parameters with cost, size, and environmental factors to develop effective soft multifunctional sensors for a wide range of applications.The article discusses the development and future directions of soft multifunctional sensors in the context of flexible electronics. These sensors are essential components of next-generation flexible electronics and have gained significant research interest due to their ability to detect multiple stimuli, such as strain, pressure, vibration, temperature, humidity, and biochemical markers. The review highlights key characteristics of these sensors, including their flexibility and multifunctionality, and emphasizes the importance of selecting appropriate materials and structures to meet specific application requirements. The article also discusses emerging materials and structures, such as carbon-based materials and MXene-based materials, which offer unique advantages in terms of electrical conductivity, mechanical strength, and sensitivity. The review outlines future research directions, including the decoupling of multiple stimuli, data processing, skin conformability, and energy sources. It also addresses challenges and opportunities for these sensors in the coming decade, emphasizing the need for further advancements in materials, manufacturing techniques, and sensor design to enhance their performance and practicality. The article concludes by emphasizing the importance of balancing performance parameters with cost, size, and environmental factors to develop effective soft multifunctional sensors for a wide range of applications.