The article reviews the aging-related factors that contribute to the development and progression of osteoarthritis (OA). It highlights several key mechanisms, including age-related inflammation (inflammaging), cellular senescence, mitochondrial dysfunction, oxidative stress, and altered energy metabolism. These processes promote a proinflammatory and catabolic state, leading to increased joint tissue destruction and defective repair. The review also discusses the role of specific mediators such as IL-6 and the senescence-associated secretory phenotype (SASP) in OA. Additionally, it explores the impact of obesity and visceral fat on OA, as well as the potential therapeutic strategies targeting senescent cells and mitochondrial dysfunction. The authors emphasize the need for further research to understand the common mechanisms driving aging and OA, and to develop interventions that can improve healthspan and reduce the burden of this chronic condition.The article reviews the aging-related factors that contribute to the development and progression of osteoarthritis (OA). It highlights several key mechanisms, including age-related inflammation (inflammaging), cellular senescence, mitochondrial dysfunction, oxidative stress, and altered energy metabolism. These processes promote a proinflammatory and catabolic state, leading to increased joint tissue destruction and defective repair. The review also discusses the role of specific mediators such as IL-6 and the senescence-associated secretory phenotype (SASP) in OA. Additionally, it explores the impact of obesity and visceral fat on OA, as well as the potential therapeutic strategies targeting senescent cells and mitochondrial dysfunction. The authors emphasize the need for further research to understand the common mechanisms driving aging and OA, and to develop interventions that can improve healthspan and reduce the burden of this chronic condition.