The article reviews the utilization of agro-industrial wastes through solid state fermentation (SSF) to produce various valuable products. Agro-industrial wastes, rich in bioactive compounds, can be used as an alternative source for producing biogas, biofuel, mushrooms, and tempeh. SSF is a cost-effective and environmentally friendly process that uses non-soluble materials or solid substrates in the absence or near absence of free water. The review highlights the potential of SSF in converting agricultural residues into valuable products, such as biofuels, antioxidants, antibiotics, enzymes, and mushroom cultivation. The article also discusses the types of agro-industrial wastes, the composition of different substrates used in SSF, and the application of SSF in producing biofuels, antioxidants, antibiotics, enzymes, and mushrooms. The use of SSF in these processes not only reduces environmental pollution but also enhances the utilization of agricultural residues, making them a sustainable and eco-friendly resource.The article reviews the utilization of agro-industrial wastes through solid state fermentation (SSF) to produce various valuable products. Agro-industrial wastes, rich in bioactive compounds, can be used as an alternative source for producing biogas, biofuel, mushrooms, and tempeh. SSF is a cost-effective and environmentally friendly process that uses non-soluble materials or solid substrates in the absence or near absence of free water. The review highlights the potential of SSF in converting agricultural residues into valuable products, such as biofuels, antioxidants, antibiotics, enzymes, and mushroom cultivation. The article also discusses the types of agro-industrial wastes, the composition of different substrates used in SSF, and the application of SSF in producing biofuels, antioxidants, antibiotics, enzymes, and mushrooms. The use of SSF in these processes not only reduces environmental pollution but also enhances the utilization of agricultural residues, making them a sustainable and eco-friendly resource.