The article reviews the literature on the use of chitosan and alginate-based hydrogels for topical antibacterial applications. Chitosan and alginate are promising natural polymers that can enhance the effectiveness of antibacterial agents. The review highlights the potential of these hydrogels in treating various bacterial infections, including those caused by *Propionibacterium acnes*, *Corynebacterium*, *Staphylococcus epidermidis*, *Staphylococcus aureus*, and *Streptococcus pyogenes*. The hydrogel formulations are designed to deliver antibacterial agents over an extended period, reducing the risk of bacterial resistance and local side effects associated with topical antibiotics. The review also discusses the preparation methods, characterization techniques, and challenges in the development of these hydrogels. Despite their promising properties, further clinical trials are needed to ensure their safety and efficacy. The article concludes that chitosan and alginate-based hydrogels show great potential in treating topical bacterial infections and warrant further research to optimize their formulations and applications.The article reviews the literature on the use of chitosan and alginate-based hydrogels for topical antibacterial applications. Chitosan and alginate are promising natural polymers that can enhance the effectiveness of antibacterial agents. The review highlights the potential of these hydrogels in treating various bacterial infections, including those caused by *Propionibacterium acnes*, *Corynebacterium*, *Staphylococcus epidermidis*, *Staphylococcus aureus*, and *Streptococcus pyogenes*. The hydrogel formulations are designed to deliver antibacterial agents over an extended period, reducing the risk of bacterial resistance and local side effects associated with topical antibiotics. The review also discusses the preparation methods, characterization techniques, and challenges in the development of these hydrogels. Despite their promising properties, further clinical trials are needed to ensure their safety and efficacy. The article concludes that chitosan and alginate-based hydrogels show great potential in treating topical bacterial infections and warrant further research to optimize their formulations and applications.