Chitosan and alginate-based hydrogels have shown significant potential in enhancing the activity of antibacterial agents when applied topically. These natural polymers are effective in delivering various active ingredients, particularly antibacterial agents, due to their biocompatibility, biodegradability, and ability to retain moisture. The combination of chitosan and alginate in hydrogel formulations has been shown to improve bacterial inhibition, as evidenced by reduced bacterial colony counts and increased inhibition zones. This review summarizes the literature on the use of chitosan and alginate-based hydrogels for topical antibacterial applications, highlighting their advantages in drug delivery, including sustained release and enhanced penetration into target tissues. The hydrogels are compatible with a wide range of active substances, including synthetic compounds, natural extracts, and isolated compounds. Additionally, the incorporation of chitosan and alginate into hydrogel formulations helps in retaining antibacterial agents, allowing for their gradual release over an optimal period. The review also discusses the challenges and limitations of using these polymers, including the need for further clinical trials to ensure safety and efficacy. Future research should focus on exploring the potential of combining chitosan and alginate with other polymers to enhance their properties and expand their applications in treating skin infections. Overall, chitosan and alginate-based hydrogels offer a promising solution for addressing challenges in the treatment of topical bacterial infections.Chitosan and alginate-based hydrogels have shown significant potential in enhancing the activity of antibacterial agents when applied topically. These natural polymers are effective in delivering various active ingredients, particularly antibacterial agents, due to their biocompatibility, biodegradability, and ability to retain moisture. The combination of chitosan and alginate in hydrogel formulations has been shown to improve bacterial inhibition, as evidenced by reduced bacterial colony counts and increased inhibition zones. This review summarizes the literature on the use of chitosan and alginate-based hydrogels for topical antibacterial applications, highlighting their advantages in drug delivery, including sustained release and enhanced penetration into target tissues. The hydrogels are compatible with a wide range of active substances, including synthetic compounds, natural extracts, and isolated compounds. Additionally, the incorporation of chitosan and alginate into hydrogel formulations helps in retaining antibacterial agents, allowing for their gradual release over an optimal period. The review also discusses the challenges and limitations of using these polymers, including the need for further clinical trials to ensure safety and efficacy. Future research should focus on exploring the potential of combining chitosan and alginate with other polymers to enhance their properties and expand their applications in treating skin infections. Overall, chitosan and alginate-based hydrogels offer a promising solution for addressing challenges in the treatment of topical bacterial infections.