This article discusses the relationship between allergic states and vascular lesions, particularly in the context of allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Over the past 25 years, a strong link has been established between allergic conditions and vascular diseases. Researchers such as Gruber, Cohen, Kline, Young, and others have proposed that these conditions are related to hypersensitivity reactions. The study presents 13 cases of severe asthma with clinical and pathological features consistent with allergic granulomatosis, including granulomatous extravascular lesions and vascular changes. These cases were observed in patients who had a history of severe asthma, fever, and hyper-eosinophilia. The pathological findings included granulomatous nodules, necrotizing inflammation, and fibrosis in various organs. The study also highlights the presence of granulomatous lesions in connective tissue and blood vessels, suggesting that this syndrome is distinct from classical periarteritis nodosa. The authors conclude that allergic granulomatosis is a distinct entity, with a possible allergic etiology, and that it may include other allergic syndromes such as Loeffler's syndrome. The study emphasizes the importance of biopsy in diagnosing these conditions and suggests that allergic angiitis is the most severe form of the disease. The findings support the idea that allergic reactions can lead to vascular and connective tissue damage, with eosinophilic infiltration playing a key role in the pathogenesis of these conditions. The study also notes that the clinical course of these diseases can vary, with some cases being more severe and others being milder. The authors conclude that further research is needed to fully understand the mechanisms and clinical significance of these conditions.This article discusses the relationship between allergic states and vascular lesions, particularly in the context of allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Over the past 25 years, a strong link has been established between allergic conditions and vascular diseases. Researchers such as Gruber, Cohen, Kline, Young, and others have proposed that these conditions are related to hypersensitivity reactions. The study presents 13 cases of severe asthma with clinical and pathological features consistent with allergic granulomatosis, including granulomatous extravascular lesions and vascular changes. These cases were observed in patients who had a history of severe asthma, fever, and hyper-eosinophilia. The pathological findings included granulomatous nodules, necrotizing inflammation, and fibrosis in various organs. The study also highlights the presence of granulomatous lesions in connective tissue and blood vessels, suggesting that this syndrome is distinct from classical periarteritis nodosa. The authors conclude that allergic granulomatosis is a distinct entity, with a possible allergic etiology, and that it may include other allergic syndromes such as Loeffler's syndrome. The study emphasizes the importance of biopsy in diagnosing these conditions and suggests that allergic angiitis is the most severe form of the disease. The findings support the idea that allergic reactions can lead to vascular and connective tissue damage, with eosinophilic infiltration playing a key role in the pathogenesis of these conditions. The study also notes that the clinical course of these diseases can vary, with some cases being more severe and others being milder. The authors conclude that further research is needed to fully understand the mechanisms and clinical significance of these conditions.