This comprehensive review focuses on the extensive research and biological activities of Aloe vera (AV), a plant with a long history of use in traditional medicine. AV and its products have been shown to have beneficial effects on human health, both through topical and oral use. The review highlights the numerous biological activities of AV, including antiviral, antimicrobial, antitumor, and antifungal properties. It also discusses its antidepressant effects and its potential in treating various skin disorders, such as psoriasis, acne, and prediabetes. The review covers the morphology and chemical composition of AV, including its gel, latex, and leaves, and explores the components responsible for its various activities. Additionally, it addresses the commercial availability of AV components and their applications in cosmetics, food, and pharmaceuticals. The review also discusses the toxicological aspects of AV, noting that while topical use is generally safe, oral administration may have adverse effects. Recent studies on the use of AV in combination with other natural products and its potential in regenerative medicine are also covered. Overall, the review provides a detailed overview of the current understanding of AV's biological activities and its potential in various therapeutic applications.This comprehensive review focuses on the extensive research and biological activities of Aloe vera (AV), a plant with a long history of use in traditional medicine. AV and its products have been shown to have beneficial effects on human health, both through topical and oral use. The review highlights the numerous biological activities of AV, including antiviral, antimicrobial, antitumor, and antifungal properties. It also discusses its antidepressant effects and its potential in treating various skin disorders, such as psoriasis, acne, and prediabetes. The review covers the morphology and chemical composition of AV, including its gel, latex, and leaves, and explores the components responsible for its various activities. Additionally, it addresses the commercial availability of AV components and their applications in cosmetics, food, and pharmaceuticals. The review also discusses the toxicological aspects of AV, noting that while topical use is generally safe, oral administration may have adverse effects. Recent studies on the use of AV in combination with other natural products and its potential in regenerative medicine are also covered. Overall, the review provides a detailed overview of the current understanding of AV's biological activities and its potential in various therapeutic applications.