This study provides updated estimates of the prevalence of Alzheimer's disease (AD) dementia in the United States from 2010 to 2050. Using data from the Chicago Health and Aging Project (CHAP), a longitudinal, population-based study, the researchers calculated incidence probabilities for single-year age groups, races, and levels of education. These probabilities were combined with US mortality rates, education distribution, and current and projected population data to estimate the number of people with AD dementia. The results show that in 2010, there were 4.7 million individuals aged 65 or older with AD dementia, with the majority being in the 75-84 age group. By 2050, the total number of people with AD dementia is projected to reach 13.8 million, with 7.0 million aged 85 or older. The study emphasizes the need for preventive measures to address the growing burden of AD dementia on individuals, caregivers, and society.This study provides updated estimates of the prevalence of Alzheimer's disease (AD) dementia in the United States from 2010 to 2050. Using data from the Chicago Health and Aging Project (CHAP), a longitudinal, population-based study, the researchers calculated incidence probabilities for single-year age groups, races, and levels of education. These probabilities were combined with US mortality rates, education distribution, and current and projected population data to estimate the number of people with AD dementia. The results show that in 2010, there were 4.7 million individuals aged 65 or older with AD dementia, with the majority being in the 75-84 age group. By 2050, the total number of people with AD dementia is projected to reach 13.8 million, with 7.0 million aged 85 or older. The study emphasizes the need for preventive measures to address the growing burden of AD dementia on individuals, caregivers, and society.