The study investigates the functional connectivity between the amygdala and frontal cortical regions during emotion regulation, specifically through cognitive reappraisal. Using psychophysiological interaction (PPI) analyses of functional magnetic resonance imaging (fMRI) data, the researchers found that activity in specific frontal cortical areas (dorsolateral, dorsal medial, anterior cingulate, and orbital) covaries with amygdala activity, and this connectivity is dependent on the reappraisal task. The strength of coupling between the amygdala and the orbitofrontal cortex and dorsal medial prefrontal cortex predicts the extent to which negative affect is attenuated following reappraisal. These findings highlight the importance of functional connectivity within the limbic-frontal circuit during emotion regulation.The study investigates the functional connectivity between the amygdala and frontal cortical regions during emotion regulation, specifically through cognitive reappraisal. Using psychophysiological interaction (PPI) analyses of functional magnetic resonance imaging (fMRI) data, the researchers found that activity in specific frontal cortical areas (dorsolateral, dorsal medial, anterior cingulate, and orbital) covaries with amygdala activity, and this connectivity is dependent on the reappraisal task. The strength of coupling between the amygdala and the orbitofrontal cortex and dorsal medial prefrontal cortex predicts the extent to which negative affect is attenuated following reappraisal. These findings highlight the importance of functional connectivity within the limbic-frontal circuit during emotion regulation.