This study investigates the functional connectivity between the amygdala and prefrontal cortex during emotion regulation, focusing on the role of cognitive reappraisal in modulating negative emotional responses. Using psychophysiological interaction (PPI) analyses of functional magnetic resonance imaging (fMRI) data, the researchers found that specific areas of the frontal cortex, including the dorsolateral prefrontal cortex (DLPFC), dorsal medial prefrontal cortex (DMPFC), anterior cingulate cortex (ACC), and orbital prefrontal cortex (OFC), showed task-dependent functional interactions with the amygdala during reappraisal. These interactions were associated with the effectiveness of emotion regulation, as stronger coupling between the amygdala and these frontal regions predicted a greater reduction in negative affect following reappraisal. The study highlights the importance of functional connectivity within the limbic-frontal circuitry during emotion regulation. The findings suggest that the amygdala and prefrontal cortex work together to modulate emotional responses, with the prefrontal cortex exerting a top-down inhibitory effect on the amygdala. This interaction is crucial for successful emotion regulation, particularly through cognitive reappraisal strategies. The results also indicate that individual differences in amygdala-frontal connectivity may influence the effectiveness of emotion regulation, with greater connectivity associated with reduced negative affect. The study's methodology involved a task-based fMRI experiment where participants were asked to either maintain or reappraise their emotional responses to negative stimuli. The results showed that during reappraisal, there was increased functional connectivity between the amygdala and specific frontal regions, which was linked to a reduction in negative affect. These findings contribute to the understanding of the neural mechanisms underlying emotion regulation and have implications for the treatment of affective disorders. The study also acknowledges the limitations of its approach, including the use of negative stimuli only and the reliance on self-reported measures of emotional regulation. Future research is needed to further explore the role of brain regions outside the amygdala-frontal circuit in emotion regulation and to clarify the directional nature of amygdala-frontal interactions.This study investigates the functional connectivity between the amygdala and prefrontal cortex during emotion regulation, focusing on the role of cognitive reappraisal in modulating negative emotional responses. Using psychophysiological interaction (PPI) analyses of functional magnetic resonance imaging (fMRI) data, the researchers found that specific areas of the frontal cortex, including the dorsolateral prefrontal cortex (DLPFC), dorsal medial prefrontal cortex (DMPFC), anterior cingulate cortex (ACC), and orbital prefrontal cortex (OFC), showed task-dependent functional interactions with the amygdala during reappraisal. These interactions were associated with the effectiveness of emotion regulation, as stronger coupling between the amygdala and these frontal regions predicted a greater reduction in negative affect following reappraisal. The study highlights the importance of functional connectivity within the limbic-frontal circuitry during emotion regulation. The findings suggest that the amygdala and prefrontal cortex work together to modulate emotional responses, with the prefrontal cortex exerting a top-down inhibitory effect on the amygdala. This interaction is crucial for successful emotion regulation, particularly through cognitive reappraisal strategies. The results also indicate that individual differences in amygdala-frontal connectivity may influence the effectiveness of emotion regulation, with greater connectivity associated with reduced negative affect. The study's methodology involved a task-based fMRI experiment where participants were asked to either maintain or reappraise their emotional responses to negative stimuli. The results showed that during reappraisal, there was increased functional connectivity between the amygdala and specific frontal regions, which was linked to a reduction in negative affect. These findings contribute to the understanding of the neural mechanisms underlying emotion regulation and have implications for the treatment of affective disorders. The study also acknowledges the limitations of its approach, including the use of negative stimuli only and the reliance on self-reported measures of emotional regulation. Future research is needed to further explore the role of brain regions outside the amygdala-frontal circuit in emotion regulation and to clarify the directional nature of amygdala-frontal interactions.