The article discusses the Earth-system perspective of the global nitrogen cycle, emphasizing the increasing human impact on this cycle and its interactions with the carbon cycle and climate. The production and use of artificial nitrogen fertilizers have significantly increased food production but also led to environmental issues such as eutrophication and global acidification. The authors highlight the need to study the interactions between nitrogen and other major biogeochemical cycles, particularly carbon, to understand their combined effects on climate change. They argue that the availability of nitrogen can affect the Earth's biosphere's ability to absorb atmospheric carbon, which is crucial for mitigating climate change. The article also explores the anthropogenic perturbation of the nitrogen cycle, the interactions with other element cycles, and the potential future impacts on the carbon cycle and climate. It concludes by emphasizing the importance of reducing fossil fuel burning to mitigate the threats associated with human activity in the Anthropocene.The article discusses the Earth-system perspective of the global nitrogen cycle, emphasizing the increasing human impact on this cycle and its interactions with the carbon cycle and climate. The production and use of artificial nitrogen fertilizers have significantly increased food production but also led to environmental issues such as eutrophication and global acidification. The authors highlight the need to study the interactions between nitrogen and other major biogeochemical cycles, particularly carbon, to understand their combined effects on climate change. They argue that the availability of nitrogen can affect the Earth's biosphere's ability to absorb atmospheric carbon, which is crucial for mitigating climate change. The article also explores the anthropogenic perturbation of the nitrogen cycle, the interactions with other element cycles, and the potential future impacts on the carbon cycle and climate. It concludes by emphasizing the importance of reducing fossil fuel burning to mitigate the threats associated with human activity in the Anthropocene.