Poly(lactic-co-glycolic) acid (PLGA) is a biodegradable and biocompatible polymer widely used in bone tissue engineering due to its tunable degradation rate, mechanical properties, and ability to be modified for better interaction with biological materials. This review discusses the current state of PLGA-based materials for bone tissue engineering, highlighting their potential in scaffolds, fibrous structures, hydrogels, and injectable microspheres. PLGA is often combined with hydroxyapatite (HA) to enhance osteoconductivity and mechanical strength. The review also covers the synthesis methods of PLGA, including solution polycondensation, ring-opening polymerization, and enzymatic polymerization, and discusses the physico-chemical properties that influence degradation and biocompatibility. Various techniques for fabricating PLGA-based scaffolds, such as porogen leaching, thermally induced phase separation, and solid freeform fabrication, are described. The review also addresses the use of functionalization strategies, such as surface modification and the incorporation of bioactive molecules, to improve cell adhesion and bone regeneration. The potential of PLGA in bone tissue engineering is highlighted, along with the challenges and future directions in the development of functionalized PLGA constructs for enhanced bone regeneration.Poly(lactic-co-glycolic) acid (PLGA) is a biodegradable and biocompatible polymer widely used in bone tissue engineering due to its tunable degradation rate, mechanical properties, and ability to be modified for better interaction with biological materials. This review discusses the current state of PLGA-based materials for bone tissue engineering, highlighting their potential in scaffolds, fibrous structures, hydrogels, and injectable microspheres. PLGA is often combined with hydroxyapatite (HA) to enhance osteoconductivity and mechanical strength. The review also covers the synthesis methods of PLGA, including solution polycondensation, ring-opening polymerization, and enzymatic polymerization, and discusses the physico-chemical properties that influence degradation and biocompatibility. Various techniques for fabricating PLGA-based scaffolds, such as porogen leaching, thermally induced phase separation, and solid freeform fabrication, are described. The review also addresses the use of functionalization strategies, such as surface modification and the incorporation of bioactive molecules, to improve cell adhesion and bone regeneration. The potential of PLGA in bone tissue engineering is highlighted, along with the challenges and future directions in the development of functionalized PLGA constructs for enhanced bone regeneration.