The article describes an innovative DNA sequencing technology that leverages scalable, low-cost semiconductor manufacturing techniques to create an integrated circuit capable of performing non-optical DNA sequencing. The technology uses ion-sensitive field-effect transistors (ISFETs) to detect ions produced by DNA polymerase synthesis, enabling direct and parallel detection of multiple sequencing reactions. The device, fabricated using complementary metal-oxide semiconductor (CMOS) processes, allows for large-scale production and high-density arrays. The system's performance is demonstrated through the sequencing of three bacterial genomes and a human genome, achieving high accuracy and coverage. The technology's scalability and cost-effectiveness make it a promising solution for future genome sequencing applications, aligning with the goal of achieving a $1,000 genome.The article describes an innovative DNA sequencing technology that leverages scalable, low-cost semiconductor manufacturing techniques to create an integrated circuit capable of performing non-optical DNA sequencing. The technology uses ion-sensitive field-effect transistors (ISFETs) to detect ions produced by DNA polymerase synthesis, enabling direct and parallel detection of multiple sequencing reactions. The device, fabricated using complementary metal-oxide semiconductor (CMOS) processes, allows for large-scale production and high-density arrays. The system's performance is demonstrated through the sequencing of three bacterial genomes and a human genome, achieving high accuracy and coverage. The technology's scalability and cost-effectiveness make it a promising solution for future genome sequencing applications, aligning with the goal of achieving a $1,000 genome.