The paper presents an overview of the Pesticides Properties DataBase (PPDB), a comprehensive, free-to-access database developed to support pesticide risk assessments. Initiated in 1996, the PPDB has evolved over 20 years to meet the growing needs of risk assessment, incorporating data on over 2300 pesticide active substances and more than 700 metabolites. The database stores over 300 parameters for each substance, covering human health, environmental quality, and biodiversity risk assessments. It includes data from regulatory dossiers, peer-reviewed publications, and manufacturer datasheets, and is validated and quality-controlled to ensure reliability. The PPDB is designed to be flexible, allowing for the incorporation of new data and parameters as needed. It provides a transparent, harmonized dataset that supports a wide range of risk assessment applications, including environmental fate, ecotoxicology, and human health assessments. The database is used globally, with increasing usage and citations in scientific literature. It has been applied in various risk assessment scenarios, including pesticide taxation in Denmark, environmental risk assessments in Italy, and ecological risk indices for pesticide mixtures. The PPDB supports regulatory and non-regulatory risk assessments, and is used by governments, researchers, and industry for pesticide risk management. It is also integrated with decision support systems and models, such as MACRO and VULPES, to assess pesticide impacts on the environment and human health. The database has been peer-reviewed and is endorsed by organizations such as IUPAC and the FAO. Despite its extensive use, the PPDB faces challenges in data quality and completeness, particularly in non-regulatory applications where data may be less comprehensive. The database continues to evolve to meet the increasing complexity of risk assessments, with a focus on expanding parameters related to human toxicology and pesticide mixtures. The PPDB plays a crucial role in supporting pesticide risk assessments globally, providing a reliable and comprehensive source of data for environmental and health risk management.The paper presents an overview of the Pesticides Properties DataBase (PPDB), a comprehensive, free-to-access database developed to support pesticide risk assessments. Initiated in 1996, the PPDB has evolved over 20 years to meet the growing needs of risk assessment, incorporating data on over 2300 pesticide active substances and more than 700 metabolites. The database stores over 300 parameters for each substance, covering human health, environmental quality, and biodiversity risk assessments. It includes data from regulatory dossiers, peer-reviewed publications, and manufacturer datasheets, and is validated and quality-controlled to ensure reliability. The PPDB is designed to be flexible, allowing for the incorporation of new data and parameters as needed. It provides a transparent, harmonized dataset that supports a wide range of risk assessment applications, including environmental fate, ecotoxicology, and human health assessments. The database is used globally, with increasing usage and citations in scientific literature. It has been applied in various risk assessment scenarios, including pesticide taxation in Denmark, environmental risk assessments in Italy, and ecological risk indices for pesticide mixtures. The PPDB supports regulatory and non-regulatory risk assessments, and is used by governments, researchers, and industry for pesticide risk management. It is also integrated with decision support systems and models, such as MACRO and VULPES, to assess pesticide impacts on the environment and human health. The database has been peer-reviewed and is endorsed by organizations such as IUPAC and the FAO. Despite its extensive use, the PPDB faces challenges in data quality and completeness, particularly in non-regulatory applications where data may be less comprehensive. The database continues to evolve to meet the increasing complexity of risk assessments, with a focus on expanding parameters related to human toxicology and pesticide mixtures. The PPDB plays a crucial role in supporting pesticide risk assessments globally, providing a reliable and comprehensive source of data for environmental and health risk management.