The article discusses the development and significance of the Pesticides Properties DataBase (PPDB), a comprehensive database for pesticide risk assessments. Initiated in 1996, the PPDB aims to provide a free, transparent, and harmonized dataset for all types of pesticide risk assessments. Over the past 20 years, the database has expanded to include data for nearly 2300 pesticide active substances and over 700 metabolites, with around 300 parameters per substance covering human health, environmental quality, and biodiversity risk assessments. The database has been validated and peer-reviewed, and it is widely used in regulatory and non-regulatory contexts, including by major organizations like the FAO. The article highlights the challenges in collating comprehensive datasets for pesticide risk assessments and the importance of the PPDB in addressing these issues. It also describes the data sources, quality management processes, and applications of the PPDB in various risk assessment studies, emphasizing its global usage and potential for future expansion.The article discusses the development and significance of the Pesticides Properties DataBase (PPDB), a comprehensive database for pesticide risk assessments. Initiated in 1996, the PPDB aims to provide a free, transparent, and harmonized dataset for all types of pesticide risk assessments. Over the past 20 years, the database has expanded to include data for nearly 2300 pesticide active substances and over 700 metabolites, with around 300 parameters per substance covering human health, environmental quality, and biodiversity risk assessments. The database has been validated and peer-reviewed, and it is widely used in regulatory and non-regulatory contexts, including by major organizations like the FAO. The article highlights the challenges in collating comprehensive datasets for pesticide risk assessments and the importance of the PPDB in addressing these issues. It also describes the data sources, quality management processes, and applications of the PPDB in various risk assessment studies, emphasizing its global usage and potential for future expansion.