This study investigates the ion-exchange properties of hydrotalcite-like compounds (HT) in their NO₃⁻, Cl⁻, and SO₄²⁻ forms, and their ability to exchange with various anions such as F⁻, Cl⁻, Br⁻, I⁻, OH⁻, SO₄²⁻, CO₃²⁻, and Naphthol Yellow S (NYS²⁻). The ion-exchange equilibrium constants for monovalent anions are ranked as OH⁻ > F⁻ > Cl⁻ > Br⁻ > NO₃⁻ > I⁻, while for divalent anions, they are CO₃²⁻ > NYS²⁻ > SO₄²⁻. The study found that the ion-exchange equilibrium constants tend to increase as the anion diameters decrease, and the crystallite size in the 001 direction tends to increase with anions that exhibit higher selectivity. The OH-form of HT has the smallest basal spacing and the largest crystallite size in the 001 direction. The results suggest that HT can be used for the removal of specific anions from waste waters and for the neutralization and thermal stabilization of halogen-containing polymers.This study investigates the ion-exchange properties of hydrotalcite-like compounds (HT) in their NO₃⁻, Cl⁻, and SO₄²⁻ forms, and their ability to exchange with various anions such as F⁻, Cl⁻, Br⁻, I⁻, OH⁻, SO₄²⁻, CO₃²⁻, and Naphthol Yellow S (NYS²⁻). The ion-exchange equilibrium constants for monovalent anions are ranked as OH⁻ > F⁻ > Cl⁻ > Br⁻ > NO₃⁻ > I⁻, while for divalent anions, they are CO₃²⁻ > NYS²⁻ > SO₄²⁻. The study found that the ion-exchange equilibrium constants tend to increase as the anion diameters decrease, and the crystallite size in the 001 direction tends to increase with anions that exhibit higher selectivity. The OH-form of HT has the smallest basal spacing and the largest crystallite size in the 001 direction. The results suggest that HT can be used for the removal of specific anions from waste waters and for the neutralization and thermal stabilization of halogen-containing polymers.