The article reviews the anti-biofilm activity of marine algae-derived bioactive compounds. Biofilms, complex microbial communities embedded in extracellular matrices, pose significant challenges in healthcare and food industries due to their resistance to antibiotics and ability to cause infections. Marine algae, rich in bioactive compounds such as carotenoids and polysaccharides, have shown potential in inhibiting biofilm formation. The review highlights the structural and physiological attributes of biofilms, the quorum sensing signaling network, and the role of quorum sensing inhibition in controlling biofilm-related infections. Marine algae, including macroalgae and microalgae, have been identified as sources of bioactive compounds that can disrupt biofilm formation by inhibiting quorum sensing, altering cell adhesion, and disrupting extracellular matrix structure. Specific algae species, such as *Delisea pulchra*, *Padina pavonica*, and *Chondrus crispus*, have demonstrated anti-biofilm activities against various pathogens. The article also discusses the anti-biofilm properties of algae extracts and their derivatives, including polysaccharides, carotenoids, lipids, and phlorotannins. Additionally, the use of marine-based anti-biofilm agents in the form of nanoparticles, such as silver and copper nanoparticles, is explored for their potential in combating biofilm formation. The review concludes by emphasizing the importance of marine algae as a novel source of bioactive compounds for controlling biofilm-related infections.The article reviews the anti-biofilm activity of marine algae-derived bioactive compounds. Biofilms, complex microbial communities embedded in extracellular matrices, pose significant challenges in healthcare and food industries due to their resistance to antibiotics and ability to cause infections. Marine algae, rich in bioactive compounds such as carotenoids and polysaccharides, have shown potential in inhibiting biofilm formation. The review highlights the structural and physiological attributes of biofilms, the quorum sensing signaling network, and the role of quorum sensing inhibition in controlling biofilm-related infections. Marine algae, including macroalgae and microalgae, have been identified as sources of bioactive compounds that can disrupt biofilm formation by inhibiting quorum sensing, altering cell adhesion, and disrupting extracellular matrix structure. Specific algae species, such as *Delisea pulchra*, *Padina pavonica*, and *Chondrus crispus*, have demonstrated anti-biofilm activities against various pathogens. The article also discusses the anti-biofilm properties of algae extracts and their derivatives, including polysaccharides, carotenoids, lipids, and phlorotannins. Additionally, the use of marine-based anti-biofilm agents in the form of nanoparticles, such as silver and copper nanoparticles, is explored for their potential in combating biofilm formation. The review concludes by emphasizing the importance of marine algae as a novel source of bioactive compounds for controlling biofilm-related infections.