The article reviews the anti-inflammatory benefits of semaglutide, a GLP-1 analogue used to treat type 2 diabetes. Semaglutide not only lowers blood glucose levels but also exhibits potential anti-inflammatory effects, which are crucial in managing diabetic complications such as insulin resistance and inflammation. The review discusses the latest findings on semaglutide's anti-inflammatory mechanisms, including its ability to reduce inflammatory cytokine levels and modulate immune system activity. Clinical studies have shown that semaglutide can reduce circulating inflammatory cytokines and improve renal function in patients with type 2 diabetes. Additionally, semaglutide has been found to protect the cardiovascular system by reducing inflammation and improving endothelial function. The article highlights the importance of understanding these anti-inflammatory effects to develop more effective therapeutic strategies for diabetes and its complications.The article reviews the anti-inflammatory benefits of semaglutide, a GLP-1 analogue used to treat type 2 diabetes. Semaglutide not only lowers blood glucose levels but also exhibits potential anti-inflammatory effects, which are crucial in managing diabetic complications such as insulin resistance and inflammation. The review discusses the latest findings on semaglutide's anti-inflammatory mechanisms, including its ability to reduce inflammatory cytokine levels and modulate immune system activity. Clinical studies have shown that semaglutide can reduce circulating inflammatory cytokines and improve renal function in patients with type 2 diabetes. Additionally, semaglutide has been found to protect the cardiovascular system by reducing inflammation and improving endothelial function. The article highlights the importance of understanding these anti-inflammatory effects to develop more effective therapeutic strategies for diabetes and its complications.