This study evaluated the antimicrobial activity of plant extracts and phytochemicals against both susceptible and antibiotic-resistant microorganisms. The extracts from *Caryophyllus aromaticus* (clove) and *Syzygium jambolanum* (jambolan) showed the highest antimicrobial potential, inhibiting 64.2% and 57.1% of the tested microorganisms, respectively, with a higher activity against antibiotic-resistant bacteria (83.3%). Sage and yarrow extracts did not exhibit any antimicrobial activity. The association of antibiotics with plant extracts demonstrated synergistic antibacterial activity against antibiotic-resistant bacteria, particularly *Pseudomonas aeruginosa*, which was inhibited by clove, jambolan, pomegranate, and thyme extracts. The results suggest that plant extracts and phytochemicals can be valuable in the treatment of infections caused by antibiotic-resistant microbes, and their use in combination with antibiotics may enhance therapeutic outcomes.This study evaluated the antimicrobial activity of plant extracts and phytochemicals against both susceptible and antibiotic-resistant microorganisms. The extracts from *Caryophyllus aromaticus* (clove) and *Syzygium jambolanum* (jambolan) showed the highest antimicrobial potential, inhibiting 64.2% and 57.1% of the tested microorganisms, respectively, with a higher activity against antibiotic-resistant bacteria (83.3%). Sage and yarrow extracts did not exhibit any antimicrobial activity. The association of antibiotics with plant extracts demonstrated synergistic antibacterial activity against antibiotic-resistant bacteria, particularly *Pseudomonas aeruginosa*, which was inhibited by clove, jambolan, pomegranate, and thyme extracts. The results suggest that plant extracts and phytochemicals can be valuable in the treatment of infections caused by antibiotic-resistant microbes, and their use in combination with antibiotics may enhance therapeutic outcomes.