The article "Antibiotic Resistance: A Rundown of a Global Crisis" published in *Infection and Drug Resistance* highlights the critical issue of antibiotic resistance, which is a growing threat to human, animal, and environmental health. The misuse of antibiotics and the lack of new drug development due to stringent regulatory requirements and reduced financial incentives have contributed to the crisis. The article emphasizes the need for comprehensive efforts to study emerging microorganisms, resistance mechanisms, and antimicrobial agents, as well as multidisciplinary approaches across healthcare, environmental, and agricultural sectors. Alternative therapies such as probiotics, antibodies, and vaccines show promise in trials and could serve as preventive or adjunctive treatments. The economic impact of antibiotic resistance is significant, with annual losses in the US alone reaching billions of dollars. The discovery and development of new antibiotics have been crucial in modern medicine, but the emergence of multidrug-resistant (MDR) bacteria poses a serious challenge. The article discusses the multifaceted causes of antibiotic resistance, including overuse, poor sanitation, and environmental factors, and highlights the importance of global action plans and coordinated efforts to address this crisis. It also explores the role of nanotechnology, antimicrobial peptides, and alternative therapies in combating antibiotic resistance. The conclusion underscores the need for increased knowledge, data collection, and a global, interdisciplinary approach to control and manage the "global resistome."The article "Antibiotic Resistance: A Rundown of a Global Crisis" published in *Infection and Drug Resistance* highlights the critical issue of antibiotic resistance, which is a growing threat to human, animal, and environmental health. The misuse of antibiotics and the lack of new drug development due to stringent regulatory requirements and reduced financial incentives have contributed to the crisis. The article emphasizes the need for comprehensive efforts to study emerging microorganisms, resistance mechanisms, and antimicrobial agents, as well as multidisciplinary approaches across healthcare, environmental, and agricultural sectors. Alternative therapies such as probiotics, antibodies, and vaccines show promise in trials and could serve as preventive or adjunctive treatments. The economic impact of antibiotic resistance is significant, with annual losses in the US alone reaching billions of dollars. The discovery and development of new antibiotics have been crucial in modern medicine, but the emergence of multidrug-resistant (MDR) bacteria poses a serious challenge. The article discusses the multifaceted causes of antibiotic resistance, including overuse, poor sanitation, and environmental factors, and highlights the importance of global action plans and coordinated efforts to address this crisis. It also explores the role of nanotechnology, antimicrobial peptides, and alternative therapies in combating antibiotic resistance. The conclusion underscores the need for increased knowledge, data collection, and a global, interdisciplinary approach to control and manage the "global resistome."