The article "Antibiotic Resistance of Bacterial Biofilms" by Niels Heiby, Thomas Bjarnsholt, Michael Givskov, Søren Molin, and Oana Ciofu, published in the International Journal of Antimicrobial Agents, discusses the mechanisms and implications of antibiotic resistance in bacterial biofilms. Biofilms are structured communities of bacteria embedded in a self-produced polymer matrix, which can cause chronic infections due to increased tolerance to antibiotics, disinfectants, and resistance to phagocytosis. The persistence of infections like staphylococcal infections related to foreign bodies and chronic *Pseudomonas aeruginosa* lung infections in cystic fibrosis patients is attributed to biofilm formation. Biofilms exhibit nutrient and oxygen gradients, leading to decreased metabolic activity and increased doubling times of bacterial cells, which contribute to their tolerance to antibiotics. Conventional resistance mechanisms such as chromosomal beta-lactamase, up-regulated efflux pumps, and mutations in antibiotic target molecules also play a role in biofilm survival. The article highlights the importance of early aggressive antibiotic prophylaxis or therapy and chronic suppressive therapy in preventing and treating biofilms. Additionally, the use of enzymes that dissolve the biofilm matrix (e.g., DNase, alginate lyase) and quorum sensing inhibitors, which increase biofilm susceptibility to antibiotics, are promising strategies. The authors also discuss the role of quorum sensing in biofilm development and its impact on antibiotic resistance, emphasizing the potential of quorum sensing inhibitors as therapeutic agents.The article "Antibiotic Resistance of Bacterial Biofilms" by Niels Heiby, Thomas Bjarnsholt, Michael Givskov, Søren Molin, and Oana Ciofu, published in the International Journal of Antimicrobial Agents, discusses the mechanisms and implications of antibiotic resistance in bacterial biofilms. Biofilms are structured communities of bacteria embedded in a self-produced polymer matrix, which can cause chronic infections due to increased tolerance to antibiotics, disinfectants, and resistance to phagocytosis. The persistence of infections like staphylococcal infections related to foreign bodies and chronic *Pseudomonas aeruginosa* lung infections in cystic fibrosis patients is attributed to biofilm formation. Biofilms exhibit nutrient and oxygen gradients, leading to decreased metabolic activity and increased doubling times of bacterial cells, which contribute to their tolerance to antibiotics. Conventional resistance mechanisms such as chromosomal beta-lactamase, up-regulated efflux pumps, and mutations in antibiotic target molecules also play a role in biofilm survival. The article highlights the importance of early aggressive antibiotic prophylaxis or therapy and chronic suppressive therapy in preventing and treating biofilms. Additionally, the use of enzymes that dissolve the biofilm matrix (e.g., DNase, alginate lyase) and quorum sensing inhibitors, which increase biofilm susceptibility to antibiotics, are promising strategies. The authors also discuss the role of quorum sensing in biofilm development and its impact on antibiotic resistance, emphasizing the potential of quorum sensing inhibitors as therapeutic agents.