Antibiotic resistance has become a major global health issue, with resistant bacteria causing significant morbidity and mortality. The review discusses the factors contributing to this phenomenon, including economic impact, intrinsic and acquired resistance, and the means of infection. It also addresses the decline in antibiotic development and the approaches scientists are using to find new antibacterial agents. The review highlights the importance of developing new antibiotics and the challenges in doing so, including regulatory hurdles and the high cost of development. It also discusses the role of public misconceptions and over-prescription in the spread of resistance. The review covers various bacterial threats, including MRSA, VRE, and resistant strains of gram-negative bacteria. It also discusses the development of new antibiotics and the need for innovative approaches to combat antibiotic resistance. The review concludes that the development of new antibiotics is essential to address the growing threat of antibiotic resistance.Antibiotic resistance has become a major global health issue, with resistant bacteria causing significant morbidity and mortality. The review discusses the factors contributing to this phenomenon, including economic impact, intrinsic and acquired resistance, and the means of infection. It also addresses the decline in antibiotic development and the approaches scientists are using to find new antibacterial agents. The review highlights the importance of developing new antibiotics and the challenges in doing so, including regulatory hurdles and the high cost of development. It also discusses the role of public misconceptions and over-prescription in the spread of resistance. The review covers various bacterial threats, including MRSA, VRE, and resistant strains of gram-negative bacteria. It also discusses the development of new antibiotics and the need for innovative approaches to combat antibiotic resistance. The review concludes that the development of new antibiotics is essential to address the growing threat of antibiotic resistance.