Antimicrobial resistance (AMR) is a major global health threat that has serious implications for public health, leading to increased healthcare costs, prolonged hospital stays, and higher mortality rates. Despite efforts to address AMR, its prevalence continues to rise due to factors such as the overuse and misuse of antibiotics in healthcare and agriculture, as well as natural bacterial evolution and horizontal gene transfer. The article reviews studies published between 2012 and 2019, highlighting the economic, healthcare, and patient-level impacts of AMR. It notes that AMR has led to an estimated 700,000 deaths annually and could result in 10 million deaths by 2050 if no action is taken. The economic burden is also significant, with the U.S. alone facing annual healthcare costs of up to $2 billion. AMR also affects livestock production, reducing protein availability and increasing food prices. The article emphasizes the need for global collaboration to combat AMR, including improved surveillance, policy changes, and public awareness. It calls for a coordinated approach involving governments, healthcare providers, researchers, and the public to mitigate the growing threat of AMR.Antimicrobial resistance (AMR) is a major global health threat that has serious implications for public health, leading to increased healthcare costs, prolonged hospital stays, and higher mortality rates. Despite efforts to address AMR, its prevalence continues to rise due to factors such as the overuse and misuse of antibiotics in healthcare and agriculture, as well as natural bacterial evolution and horizontal gene transfer. The article reviews studies published between 2012 and 2019, highlighting the economic, healthcare, and patient-level impacts of AMR. It notes that AMR has led to an estimated 700,000 deaths annually and could result in 10 million deaths by 2050 if no action is taken. The economic burden is also significant, with the U.S. alone facing annual healthcare costs of up to $2 billion. AMR also affects livestock production, reducing protein availability and increasing food prices. The article emphasizes the need for global collaboration to combat AMR, including improved surveillance, policy changes, and public awareness. It calls for a coordinated approach involving governments, healthcare providers, researchers, and the public to mitigate the growing threat of AMR.