Antimicrobial resistance (AMR) poses a significant threat to public health, causing challenges in the prevention and treatment of persistent diseases. Despite efforts to address this issue, global AMR trends show no signs of slowing down. Misuse and overuse of antibacterial agents in healthcare and agriculture, as well as the spontaneous evolution and horizontal gene transfer of bacteria, are major contributors to AMR. The financial consequences of AMR are severe, including increased healthcare costs due to higher hospital admissions and drug usage. A literature review, conducted using Scopus, PubMed, and Google Scholar, identified three levels of impact: patient, healthcare, and economic. While there are gaps in knowledge and areas for improvement, there is a lack of progress in ending the persistent trends of AMR. The article highlights the need for collective action, political momentum, and robust multisectoral collaboration to combat AMR and mitigate its adverse impacts on society and the economy.Antimicrobial resistance (AMR) poses a significant threat to public health, causing challenges in the prevention and treatment of persistent diseases. Despite efforts to address this issue, global AMR trends show no signs of slowing down. Misuse and overuse of antibacterial agents in healthcare and agriculture, as well as the spontaneous evolution and horizontal gene transfer of bacteria, are major contributors to AMR. The financial consequences of AMR are severe, including increased healthcare costs due to higher hospital admissions and drug usage. A literature review, conducted using Scopus, PubMed, and Google Scholar, identified three levels of impact: patient, healthcare, and economic. While there are gaps in knowledge and areas for improvement, there is a lack of progress in ending the persistent trends of AMR. The article highlights the need for collective action, political momentum, and robust multisectoral collaboration to combat AMR and mitigate its adverse impacts on society and the economy.