Antimicrobial resistance (AMR) is a major global public health issue, driven by antibiotic overuse. Overprescribing increases adverse effects, re-attendance, and unnecessary medicalization of self-limiting conditions. In primary care, where most infections are viral, antibiotic overuse is a significant problem. About 90% of antibiotic prescriptions are issued by general practitioners (GPs), with respiratory tract infections being the most common reason. Multifaceted interventions, such as enforcing policies against over-the-counter sales, antimicrobial stewardship programs, clinician involvement in audits, valid point-of-care tests, delayed prescribing strategies, and improved patient communication, have proven effective in reducing antibiotic overuse. These interventions include education, communication skills training, and the use of rapid diagnostic tests like CRP and procalcitonin, which help clinicians make informed decisions. Delayed prescribing, where antibiotics are prescribed but not immediately taken, has also shown promise in reducing antibiotic use without compromising patient outcomes. Effective communication with patients is crucial to manage expectations and reduce unnecessary antibiotic use. Studies show that educating patients about the natural course of infections and the risks of antibiotics can lead to reduced prescriptions. Overall, reducing antibiotic use is essential to combat AMR and preserve the effectiveness of antibiotics for future generations.Antimicrobial resistance (AMR) is a major global public health issue, driven by antibiotic overuse. Overprescribing increases adverse effects, re-attendance, and unnecessary medicalization of self-limiting conditions. In primary care, where most infections are viral, antibiotic overuse is a significant problem. About 90% of antibiotic prescriptions are issued by general practitioners (GPs), with respiratory tract infections being the most common reason. Multifaceted interventions, such as enforcing policies against over-the-counter sales, antimicrobial stewardship programs, clinician involvement in audits, valid point-of-care tests, delayed prescribing strategies, and improved patient communication, have proven effective in reducing antibiotic overuse. These interventions include education, communication skills training, and the use of rapid diagnostic tests like CRP and procalcitonin, which help clinicians make informed decisions. Delayed prescribing, where antibiotics are prescribed but not immediately taken, has also shown promise in reducing antibiotic use without compromising patient outcomes. Effective communication with patients is crucial to manage expectations and reduce unnecessary antibiotic use. Studies show that educating patients about the natural course of infections and the risks of antibiotics can lead to reduced prescriptions. Overall, reducing antibiotic use is essential to combat AMR and preserve the effectiveness of antibiotics for future generations.