Antimicrobial resistance (AMR) is a significant global health challenge, exacerbated by the overuse of antibiotics. This overprescribing, particularly in primary care, leads to increased resistance, adverse effects, and higher healthcare costs. Multifaceted interventions, including enforcing policies against over-the-counter antibiotic sales, implementing antimicrobial stewardship programs, active clinician participation in audits, using rapid point-of-care tests, promoting delayed antibiotic prescribing, and enhancing communication skills with patients, have been shown to effectively reduce antibiotic overuse. These strategies are crucial for preserving the effectiveness of antibiotics and preventing the spread of resistant infections.Antimicrobial resistance (AMR) is a significant global health challenge, exacerbated by the overuse of antibiotics. This overprescribing, particularly in primary care, leads to increased resistance, adverse effects, and higher healthcare costs. Multifaceted interventions, including enforcing policies against over-the-counter antibiotic sales, implementing antimicrobial stewardship programs, active clinician participation in audits, using rapid point-of-care tests, promoting delayed antibiotic prescribing, and enhancing communication skills with patients, have been shown to effectively reduce antibiotic overuse. These strategies are crucial for preserving the effectiveness of antibiotics and preventing the spread of resistant infections.