Antimicrobial resistance is a growing global health issue, particularly in developing countries. In these regions, antibiotics are often misused and overused, leading to increased resistance among bacteria such as pneumococci, tuberculosis, and typhoid fever. The availability of antimicrobial drugs is limited, and in many cases, they are only accessible to the wealthy. In developing countries, the use of antibiotics is often unregulated, and patients may not complete their full course of treatment, contributing to the spread of resistance. Resistance to antimicrobial drugs is causing increasing mortality and morbidity from infectious diseases. In particular, pneumococcal meningitis, tuberculosis, and typhoid fever are affected by resistance. The emergence of multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), is a significant problem in many parts of the developing world. The use of empirical treatment strategies in the absence of proper diagnostic facilities has led to overtreatment and the spread of resistant strains. Infections such as cholera, typhoid, and plague have shown increasing resistance to antibiotics, often due to the acquisition of resistance genes through plasmids. To address this issue, there is a need for improved access to diagnostic laboratories, better surveillance of resistance patterns, and more regulation of antibiotic use. Public education and training for healthcare professionals are also essential to ensure the appropriate use of antimicrobial drugs. The future must focus on improving laboratory infrastructure in developing countries to provide early warnings of resistant strains and to monitor trends in resistance. This will help in the development of effective treatment strategies and the conservation of antimicrobial drugs for future use.Antimicrobial resistance is a growing global health issue, particularly in developing countries. In these regions, antibiotics are often misused and overused, leading to increased resistance among bacteria such as pneumococci, tuberculosis, and typhoid fever. The availability of antimicrobial drugs is limited, and in many cases, they are only accessible to the wealthy. In developing countries, the use of antibiotics is often unregulated, and patients may not complete their full course of treatment, contributing to the spread of resistance. Resistance to antimicrobial drugs is causing increasing mortality and morbidity from infectious diseases. In particular, pneumococcal meningitis, tuberculosis, and typhoid fever are affected by resistance. The emergence of multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), is a significant problem in many parts of the developing world. The use of empirical treatment strategies in the absence of proper diagnostic facilities has led to overtreatment and the spread of resistant strains. Infections such as cholera, typhoid, and plague have shown increasing resistance to antibiotics, often due to the acquisition of resistance genes through plasmids. To address this issue, there is a need for improved access to diagnostic laboratories, better surveillance of resistance patterns, and more regulation of antibiotic use. Public education and training for healthcare professionals are also essential to ensure the appropriate use of antimicrobial drugs. The future must focus on improving laboratory infrastructure in developing countries to provide early warnings of resistant strains and to monitor trends in resistance. This will help in the development of effective treatment strategies and the conservation of antimicrobial drugs for future use.