Antiretroviral Therapy in Adults Updated Recommendations of the International AIDS Society–USA Panel

Antiretroviral Therapy in Adults Updated Recommendations of the International AIDS Society–USA Panel

January 19, 2000—Vol 283, No. 3 | Charles C. J. Carpenter, MD, David A. Cooper, MD, DSc, Margaret A. Fischl, MD, Jose M. Gatell, MD, PhD, Brian G. Gazzard, MA, MD, Scott M. Hammer, MD, Martin S. Hirsch, MD, Donna M. Jacobsen, BS, David A. Katzenstein, MD, Julio S. G. Montaner, MD, Douglas D. Richman, MD, Michael S. Saag, MD, Mauro Schechter, MD, PhD, Robert T. Schooley, MD, Melanie A. Thompson, MD, Stefano Vella, MD, Patrick G. Yeni, MD, Paul A. Volberding, MD
The International AIDS Society–USA panel updated its recommendations for antiretroviral therapy (ART) for adult HIV-1 infection, based on new information and available drugs. The panel, consisting of 17 international physicians with experience in antiretroviral research and HIV patient care, assessed clinical and basic science data, including phase 3 controlled trials, research conference reports, and expert opinion. The recommendations focus on the importance of adherence, long-term complications, monitoring, and new tools for managing ART. The panel emphasizes that optimal care requires individualized management and ongoing attention to scientific and clinical advancements. The availability of new antiretroviral drugs has expanded treatment options, but challenges remain, such as treatment complexity, monitoring, adherence, and long-term complications. The panel also discusses the rationale for initiating ART in established and primary HIV infection, initial therapy regimens, monitoring, drug resistance testing, and strategies for changing therapy when necessary. The recommendations aim to guide clinicians in making informed decisions about ART for their patients.The International AIDS Society–USA panel updated its recommendations for antiretroviral therapy (ART) for adult HIV-1 infection, based on new information and available drugs. The panel, consisting of 17 international physicians with experience in antiretroviral research and HIV patient care, assessed clinical and basic science data, including phase 3 controlled trials, research conference reports, and expert opinion. The recommendations focus on the importance of adherence, long-term complications, monitoring, and new tools for managing ART. The panel emphasizes that optimal care requires individualized management and ongoing attention to scientific and clinical advancements. The availability of new antiretroviral drugs has expanded treatment options, but challenges remain, such as treatment complexity, monitoring, adherence, and long-term complications. The panel also discusses the rationale for initiating ART in established and primary HIV infection, initial therapy regimens, monitoring, drug resistance testing, and strategies for changing therapy when necessary. The recommendations aim to guide clinicians in making informed decisions about ART for their patients.
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