This systematic review examines the relationship between Antonovsky's Sense of Coherence (SOC) and health, synthesizing empirical findings from 1992 to 2003. SOC, a concept from salutogenesis, is defined as an enduring attitude that enables individuals to manage stress, identify and mobilize resources, and promote effective coping. The review includes 458 scientific publications and 13 doctoral theses, analyzing the role of SOC in health outcomes across various populations and settings. Key findings indicate that SOC is strongly associated with perceived health, particularly mental health. Stronger SOC is linked to better perceived health, especially among those with high initial SOC. SOC appears to have a main, moderating, or mediating role in explaining health. It is also a predictor of health, contributing to the development and maintenance of health, though it does not fully explain overall health. SOC is positively correlated with mental health indicators such as optimism, hardiness, and self-efficacy, and negatively correlated with anxiety, depression, and stress. It is also associated with better physical health outcomes, though the relationship is weaker than with mental health. SOC has been shown to reduce the risk of circulatory health problems and improve health outcomes in various populations, including adults, children, and employees. The review highlights that SOC is a valuable resource for health promotion, enhancing resilience and promoting a positive subjective state of health. However, the study also notes limitations, such as the potential for measurement error and the need for further research to clarify the effects of SOC on health. Despite these limitations, the evidence supports the salutogenic model as a valuable approach for health promotion and disease prevention. The review concludes that SOC is an important contributor to health but is not the same as health itself. It is a complex construct that interacts with various factors, including socioeconomic conditions and social support, to influence health outcomes. The study emphasizes the need for further research to fully understand the role of SOC in health and to implement salutogenic approaches in practice.This systematic review examines the relationship between Antonovsky's Sense of Coherence (SOC) and health, synthesizing empirical findings from 1992 to 2003. SOC, a concept from salutogenesis, is defined as an enduring attitude that enables individuals to manage stress, identify and mobilize resources, and promote effective coping. The review includes 458 scientific publications and 13 doctoral theses, analyzing the role of SOC in health outcomes across various populations and settings. Key findings indicate that SOC is strongly associated with perceived health, particularly mental health. Stronger SOC is linked to better perceived health, especially among those with high initial SOC. SOC appears to have a main, moderating, or mediating role in explaining health. It is also a predictor of health, contributing to the development and maintenance of health, though it does not fully explain overall health. SOC is positively correlated with mental health indicators such as optimism, hardiness, and self-efficacy, and negatively correlated with anxiety, depression, and stress. It is also associated with better physical health outcomes, though the relationship is weaker than with mental health. SOC has been shown to reduce the risk of circulatory health problems and improve health outcomes in various populations, including adults, children, and employees. The review highlights that SOC is a valuable resource for health promotion, enhancing resilience and promoting a positive subjective state of health. However, the study also notes limitations, such as the potential for measurement error and the need for further research to clarify the effects of SOC on health. Despite these limitations, the evidence supports the salutogenic model as a valuable approach for health promotion and disease prevention. The review concludes that SOC is an important contributor to health but is not the same as health itself. It is a complex construct that interacts with various factors, including socioeconomic conditions and social support, to influence health outcomes. The study emphasizes the need for further research to fully understand the role of SOC in health and to implement salutogenic approaches in practice.