Apigenin, a powerful flavone compound found in various fruits and vegetables, exhibits numerous health-promoting benefits. It has been extensively studied for its potential as an anti-inflammatory and antioxidant compound, making it a promising candidate for reducing the risk of pathogenesis. Apigenin positively affects various bodily systems, including the respiratory, digestive, immune, and reproductive systems. It is effective in treating liver, lung, heart, kidney, neurological diseases, diabetes, and maintaining good oral and skin health. Multiple studies have shown that apigenin can suppress various types of cancer through apoptosis induction, cell-cycle arrest, suppression of cell migration and invasion, reduction of inflammation, and inhibition of angiogenesis. When used in combination with other drugs, apigenin increases their efficacy, reduces side effects, and improves chemotherapy response. This review comprehensively analyzes apigenin's potential in disease management by modulating various biological activities and its interaction with other compounds or drugs. Further research is needed to explore its mechanism of action, safety, and efficacy in disease prevention and treatment.Apigenin, a powerful flavone compound found in various fruits and vegetables, exhibits numerous health-promoting benefits. It has been extensively studied for its potential as an anti-inflammatory and antioxidant compound, making it a promising candidate for reducing the risk of pathogenesis. Apigenin positively affects various bodily systems, including the respiratory, digestive, immune, and reproductive systems. It is effective in treating liver, lung, heart, kidney, neurological diseases, diabetes, and maintaining good oral and skin health. Multiple studies have shown that apigenin can suppress various types of cancer through apoptosis induction, cell-cycle arrest, suppression of cell migration and invasion, reduction of inflammation, and inhibition of angiogenesis. When used in combination with other drugs, apigenin increases their efficacy, reduces side effects, and improves chemotherapy response. This review comprehensively analyzes apigenin's potential in disease management by modulating various biological activities and its interaction with other compounds or drugs. Further research is needed to explore its mechanism of action, safety, and efficacy in disease prevention and treatment.