Apigenin, a flavone found in fruits and vegetables, has shown promising potential in disease prevention and treatment. It exhibits anti-inflammatory and antioxidant properties, and has been found to positively affect various systems in the body, including the respiratory, digestive, immune, and reproductive systems. Apigenin is effective in treating liver, lung, heart, kidney, neurological diseases, diabetes, and maintaining good oral and skin health. It has been shown to suppress various types of cancer through the induction of apoptosis and cell-cycle arrest, suppressing cell migration and invasion, reducing inflammation, and inhibiting angiogenesis. When used in combination with other drugs, apigenin increases their efficacy, reduces the risk of side effects, and improves the response to chemotherapy. This review broadly analyzes apigenin's potential in disease management by modulating various biological activities. It also describes apigenin's interaction with other compounds or drugs and the potential role of nanoformulation in different pathogenesis. Further extensive research is needed to explore the mechanism of action, safety, and efficacy of this compound in disease prevention and treatment. Apigenin is a natural compound with a wide range of biological activities, including antioxidant, anti-inflammatory, anti-diabetic, hepatoprotective, renoprotective, cardioprotective, neuroprotective, respiratory, reproductive, skin disease, anti-obesity, anti-depressive, and anti-cancer potential. It has been shown to reduce oxidative stress, inflammation, and various pathogenesis. Apigenin is considered safe and does not cause severe toxicity even at higher doses. It has no carcinogenic or mutagenic effects. Apigenin has been found to have significant protective effects against various diseases, including cancer, diabetes, liver and kidney damage, and neurological disorders. It has also been shown to have anti-inflammatory and anti-arthritic effects. Apigenin is a promising candidate for the prevention and treatment of various diseases due to its wide range of biological activities and safety profile.Apigenin, a flavone found in fruits and vegetables, has shown promising potential in disease prevention and treatment. It exhibits anti-inflammatory and antioxidant properties, and has been found to positively affect various systems in the body, including the respiratory, digestive, immune, and reproductive systems. Apigenin is effective in treating liver, lung, heart, kidney, neurological diseases, diabetes, and maintaining good oral and skin health. It has been shown to suppress various types of cancer through the induction of apoptosis and cell-cycle arrest, suppressing cell migration and invasion, reducing inflammation, and inhibiting angiogenesis. When used in combination with other drugs, apigenin increases their efficacy, reduces the risk of side effects, and improves the response to chemotherapy. This review broadly analyzes apigenin's potential in disease management by modulating various biological activities. It also describes apigenin's interaction with other compounds or drugs and the potential role of nanoformulation in different pathogenesis. Further extensive research is needed to explore the mechanism of action, safety, and efficacy of this compound in disease prevention and treatment. Apigenin is a natural compound with a wide range of biological activities, including antioxidant, anti-inflammatory, anti-diabetic, hepatoprotective, renoprotective, cardioprotective, neuroprotective, respiratory, reproductive, skin disease, anti-obesity, anti-depressive, and anti-cancer potential. It has been shown to reduce oxidative stress, inflammation, and various pathogenesis. Apigenin is considered safe and does not cause severe toxicity even at higher doses. It has no carcinogenic or mutagenic effects. Apigenin has been found to have significant protective effects against various diseases, including cancer, diabetes, liver and kidney damage, and neurological disorders. It has also been shown to have anti-inflammatory and anti-arthritic effects. Apigenin is a promising candidate for the prevention and treatment of various diseases due to its wide range of biological activities and safety profile.