Chitosan-based hydrogels have shown great potential in promoting wound healing due to their biocompatibility, biodegradability, and antimicrobial properties. These hydrogels can be prepared through physical or chemical cross-linking methods, allowing for customization to meet specific wound healing requirements. They can be designed to respond to environmental stimuli such as pH, temperature, or light, making them "smart" hydrogels that can release therapeutic agents in a controlled manner. Additionally, chitosan-based hydrogels can be loaded with various therapeutic components, including metal ions, flavonoids, phenolic acids, plant essential oils, and peptides, to enhance their antimicrobial, anti-inflammatory, and wound-healing properties. These hydrogels have been shown to promote skin repair by accelerating hemostasis, reducing inflammation, facilitating tissue proliferation, and supporting tissue remodeling. However, challenges remain in improving the mechanical properties and long-term stability of these hydrogels. Further research is needed to optimize their performance and ensure their safety for clinical applications. Chitosan-based hydrogels represent a promising alternative to traditional wound dressings, offering a versatile and effective solution for both acute and chronic wound healing.Chitosan-based hydrogels have shown great potential in promoting wound healing due to their biocompatibility, biodegradability, and antimicrobial properties. These hydrogels can be prepared through physical or chemical cross-linking methods, allowing for customization to meet specific wound healing requirements. They can be designed to respond to environmental stimuli such as pH, temperature, or light, making them "smart" hydrogels that can release therapeutic agents in a controlled manner. Additionally, chitosan-based hydrogels can be loaded with various therapeutic components, including metal ions, flavonoids, phenolic acids, plant essential oils, and peptides, to enhance their antimicrobial, anti-inflammatory, and wound-healing properties. These hydrogels have been shown to promote skin repair by accelerating hemostasis, reducing inflammation, facilitating tissue proliferation, and supporting tissue remodeling. However, challenges remain in improving the mechanical properties and long-term stability of these hydrogels. Further research is needed to optimize their performance and ensure their safety for clinical applications. Chitosan-based hydrogels represent a promising alternative to traditional wound dressings, offering a versatile and effective solution for both acute and chronic wound healing.