The article reviews the advancements and challenges of 3D bioprinting in organ transplantation. It highlights the growing demand for organ transplants, which is currently outpaced by the supply of donor organs, leading to a significant shortage. 3D bioprinting, an additive manufacturing technique, has emerged as a promising solution by enabling the creation of patient-specific tissues and organs. The review covers the development stages of 3D bioprinting, from its early use in medical devices to its current applications in tissue and organ regeneration. It discusses the working principles of different 3D bioprinting techniques, including extrusion-based, jetting-based, and vat photopolymerization methods. Each technique is evaluated based on its advantages, disadvantages, and the factors affecting cell viability and printability. The article also explores the integration of 3D bioprinting with stem cell technology and its potential to address the donor shortage issue. Finally, it outlines the future trends and challenges in the field, emphasizing the need for further research to improve the efficiency and reliability of 3D bioprinting for organ transplantation.The article reviews the advancements and challenges of 3D bioprinting in organ transplantation. It highlights the growing demand for organ transplants, which is currently outpaced by the supply of donor organs, leading to a significant shortage. 3D bioprinting, an additive manufacturing technique, has emerged as a promising solution by enabling the creation of patient-specific tissues and organs. The review covers the development stages of 3D bioprinting, from its early use in medical devices to its current applications in tissue and organ regeneration. It discusses the working principles of different 3D bioprinting techniques, including extrusion-based, jetting-based, and vat photopolymerization methods. Each technique is evaluated based on its advantages, disadvantages, and the factors affecting cell viability and printability. The article also explores the integration of 3D bioprinting with stem cell technology and its potential to address the donor shortage issue. Finally, it outlines the future trends and challenges in the field, emphasizing the need for further research to improve the efficiency and reliability of 3D bioprinting for organ transplantation.