The article reviews the potential of mesenchymal stem cell (MSC)-derived exosomes in wound infection healing. Wound infections are common and can lead to significant patient morbidity and mortality, particularly in post-surgical patients. MSCs play a crucial role in all stages of wound healing, and their exosomes, which contain various effector proteins, messenger RNA, and microRNAs, have similar effects to the parent MSCs. These exosomes can influence the healing process by controlling the activity of target cells, making them a promising cell-free therapy. The review highlights the protective effects of MSC-derived exosomes in reducing oxidative stress and protein misfolding, improving tissue repair in burn injuries and dilated cardiomyopathy, and accelerating wound closure and skin regeneration in cutaneous wound healing models. The mechanisms by which exosomes exert their effects, including the regulation of signaling pathways and the modulation of immune responses, are discussed. The article also explores the potential of exosomes as therapeutic agents in wound infection healing, emphasizing their ability to reduce inflammation, promote angiogenesis, and enhance tissue regeneration. The review concludes by suggesting that further research is needed to optimize the use of MSC-exosomes in clinical settings, particularly in understanding their treatment mechanisms, extraction methods, and standardized production protocols.The article reviews the potential of mesenchymal stem cell (MSC)-derived exosomes in wound infection healing. Wound infections are common and can lead to significant patient morbidity and mortality, particularly in post-surgical patients. MSCs play a crucial role in all stages of wound healing, and their exosomes, which contain various effector proteins, messenger RNA, and microRNAs, have similar effects to the parent MSCs. These exosomes can influence the healing process by controlling the activity of target cells, making them a promising cell-free therapy. The review highlights the protective effects of MSC-derived exosomes in reducing oxidative stress and protein misfolding, improving tissue repair in burn injuries and dilated cardiomyopathy, and accelerating wound closure and skin regeneration in cutaneous wound healing models. The mechanisms by which exosomes exert their effects, including the regulation of signaling pathways and the modulation of immune responses, are discussed. The article also explores the potential of exosomes as therapeutic agents in wound infection healing, emphasizing their ability to reduce inflammation, promote angiogenesis, and enhance tissue regeneration. The review concludes by suggesting that further research is needed to optimize the use of MSC-exosomes in clinical settings, particularly in understanding their treatment mechanisms, extraction methods, and standardized production protocols.