Mesenchymal stem cell (MSC)-derived exosomes have shown significant potential in wound healing and infection treatment. These exosomes, released by MSCs, contain various bioactive components such as proteins, lipids, RNAs, and miRNAs, which can influence cellular processes involved in wound healing, including inflammation, angiogenesis, and tissue regeneration. MSC-exosomes have been found to reduce oxidative stress, modulate immune responses, and promote tissue repair. They have been shown to enhance wound closure, reduce chronic inflammation, and improve skin regeneration in various models. MSC-exosomes are considered a promising cell-free therapy due to their safety and efficacy compared to whole-cell therapies. They can be used to treat wound infections, which are a common complication of surgical procedures and can lead to severe sepsis. MSC-exosomes have been shown to modulate macrophage polarization, enhance angiogenesis, and promote the healing of skin wounds. They also have the potential to serve as therapeutic agents for various diseases, including cancer. Exosomes are small, membrane-bound vesicles that can be secreted by various cell types, including MSCs, and have the ability to transport genetic material and other biomolecules. The study highlights the importance of MSC-exosomes in wound healing and infection treatment, and suggests that further research is needed to fully understand their mechanisms and potential applications. The review also discusses the potential of exosomes as a therapeutic option for wound healing and infection treatment, and emphasizes the need for further research to develop effective and safe exosome-based therapies.Mesenchymal stem cell (MSC)-derived exosomes have shown significant potential in wound healing and infection treatment. These exosomes, released by MSCs, contain various bioactive components such as proteins, lipids, RNAs, and miRNAs, which can influence cellular processes involved in wound healing, including inflammation, angiogenesis, and tissue regeneration. MSC-exosomes have been found to reduce oxidative stress, modulate immune responses, and promote tissue repair. They have been shown to enhance wound closure, reduce chronic inflammation, and improve skin regeneration in various models. MSC-exosomes are considered a promising cell-free therapy due to their safety and efficacy compared to whole-cell therapies. They can be used to treat wound infections, which are a common complication of surgical procedures and can lead to severe sepsis. MSC-exosomes have been shown to modulate macrophage polarization, enhance angiogenesis, and promote the healing of skin wounds. They also have the potential to serve as therapeutic agents for various diseases, including cancer. Exosomes are small, membrane-bound vesicles that can be secreted by various cell types, including MSCs, and have the ability to transport genetic material and other biomolecules. The study highlights the importance of MSC-exosomes in wound healing and infection treatment, and suggests that further research is needed to fully understand their mechanisms and potential applications. The review also discusses the potential of exosomes as a therapeutic option for wound healing and infection treatment, and emphasizes the need for further research to develop effective and safe exosome-based therapies.