Gynecological malignancies, including endometrial carcinoma (EC), cervical carcinoma (CC), and ovarian carcinoma (CO), are prevalent diseases in women, causing significant mortality. Prevention is crucial to reduce incidence and mortality rates. However, effective screening methods are lacking for all types of gynecologic cancers. For EC, diagnosis often occurs after symptoms appear, and maintaining a low BMI and using oral contraceptives can reduce the risk. CC prevention involves early adolescence vaccination against HPV, regular screening with Pap tests and HPV tests, and early treatment of lesions. CO prevention focuses on identifying women with genetic mutations associated with increased risk, using biomarkers like CA125 and HE4 for early detection. An integrated approach combining screening, vaccination, healthy lifestyle, and risk factor management is essential for effective prevention. This approach aims to reduce discomfort, disability, and mortality, particularly in high-risk populations.Gynecological malignancies, including endometrial carcinoma (EC), cervical carcinoma (CC), and ovarian carcinoma (CO), are prevalent diseases in women, causing significant mortality. Prevention is crucial to reduce incidence and mortality rates. However, effective screening methods are lacking for all types of gynecologic cancers. For EC, diagnosis often occurs after symptoms appear, and maintaining a low BMI and using oral contraceptives can reduce the risk. CC prevention involves early adolescence vaccination against HPV, regular screening with Pap tests and HPV tests, and early treatment of lesions. CO prevention focuses on identifying women with genetic mutations associated with increased risk, using biomarkers like CA125 and HE4 for early detection. An integrated approach combining screening, vaccination, healthy lifestyle, and risk factor management is essential for effective prevention. This approach aims to reduce discomfort, disability, and mortality, particularly in high-risk populations.