Arsenic contamination is a serious global issue affecting water, soil, and public health. It is present in groundwater in over 106 countries, with 230 million people exposed to its harmful effects, including cancer, cardiovascular disease, diabetes, and developmental problems. Arsenic is highly toxic and ranked among the top 10 chemicals of public health concern by the WHO. The maximum permissible level in drinking water is 10 µg/L, set by the WHO, EPA, and EU. Effective detection, mitigation, and global collaboration are essential to address this problem. The article discusses the global scenario of arsenic contamination, its sources (anthropogenic, geogenic, and biogenic), and its impacts on the environment and human health. It also covers mitigation strategies, including detection methods, removal techniques, and the need for regulatory frameworks and public awareness. The article highlights the importance of international cooperation, research, and policy development to combat arsenic contamination and ensure safe drinking water for all. The issue is particularly severe in Asia, with countries like Bangladesh and India facing significant challenges. Other continents, including South America, Africa, Europe, Australia, and Antarctica, also have areas affected by arsenic contamination. The article emphasizes the need for innovative and cost-effective solutions, as well as the role of education and public awareness in mitigating the problem. Regulatory measures, sustainable practices, and global collaboration are crucial for addressing arsenic contamination and protecting public health.Arsenic contamination is a serious global issue affecting water, soil, and public health. It is present in groundwater in over 106 countries, with 230 million people exposed to its harmful effects, including cancer, cardiovascular disease, diabetes, and developmental problems. Arsenic is highly toxic and ranked among the top 10 chemicals of public health concern by the WHO. The maximum permissible level in drinking water is 10 µg/L, set by the WHO, EPA, and EU. Effective detection, mitigation, and global collaboration are essential to address this problem. The article discusses the global scenario of arsenic contamination, its sources (anthropogenic, geogenic, and biogenic), and its impacts on the environment and human health. It also covers mitigation strategies, including detection methods, removal techniques, and the need for regulatory frameworks and public awareness. The article highlights the importance of international cooperation, research, and policy development to combat arsenic contamination and ensure safe drinking water for all. The issue is particularly severe in Asia, with countries like Bangladesh and India facing significant challenges. Other continents, including South America, Africa, Europe, Australia, and Antarctica, also have areas affected by arsenic contamination. The article emphasizes the need for innovative and cost-effective solutions, as well as the role of education and public awareness in mitigating the problem. Regulatory measures, sustainable practices, and global collaboration are crucial for addressing arsenic contamination and protecting public health.