In 2022, the age-adjusted prevalence of diagnosed arthritis among adults aged 18 and older in the United States was 18.9%. Women were more likely than men to have arthritis, with 21.5% versus 16.1%. Arthritis prevalence increased with age, from 3.6% in adults aged 18–34 to 53.9% in those 75 and older. Black non-Hispanic, White non-Hispanic, and other and multiple-race non-Hispanic adults were more likely to have arthritis than Hispanic and Asian non-Hispanic adults. The prevalence of arthritis decreased with increasing family income, from 24.7% among those with income below 100% of the federal poverty level to 16.6% among those with income at 400% or more. Adults living in nonmetropolitan areas were more likely to have arthritis than those in more urbanized areas. Adults with higher education levels were less likely to have arthritis. Arthritis is a leading cause of disability and affects health and functioning. The report uses data from the 2022 National Health Interview Survey to describe arthritis prevalence by sociodemographic characteristics. The findings highlight disparities in arthritis prevalence by sex, age, race, income, education, urbanization level, and region. The study underscores the importance of addressing arthritis as a public health issue to reduce pain, limitations, and disability.In 2022, the age-adjusted prevalence of diagnosed arthritis among adults aged 18 and older in the United States was 18.9%. Women were more likely than men to have arthritis, with 21.5% versus 16.1%. Arthritis prevalence increased with age, from 3.6% in adults aged 18–34 to 53.9% in those 75 and older. Black non-Hispanic, White non-Hispanic, and other and multiple-race non-Hispanic adults were more likely to have arthritis than Hispanic and Asian non-Hispanic adults. The prevalence of arthritis decreased with increasing family income, from 24.7% among those with income below 100% of the federal poverty level to 16.6% among those with income at 400% or more. Adults living in nonmetropolitan areas were more likely to have arthritis than those in more urbanized areas. Adults with higher education levels were less likely to have arthritis. Arthritis is a leading cause of disability and affects health and functioning. The report uses data from the 2022 National Health Interview Survey to describe arthritis prevalence by sociodemographic characteristics. The findings highlight disparities in arthritis prevalence by sex, age, race, income, education, urbanization level, and region. The study underscores the importance of addressing arthritis as a public health issue to reduce pain, limitations, and disability.