The 2015 Asian-Pacific Clinical Practice Guidelines on the Management of Hepatitis B aim to update the recommendations for the optimal management of chronic hepatitis B virus (HBV) infection. The guidelines, developed by a panel of Asian experts, cover a wide range of care, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of liver disease stage, antiviral treatment, screening for hepatocellular carcinoma (HCC), and management in special situations. The guidelines are based on evidence from existing publications and the experts' personal experience, with recommendations graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Key areas addressed include the epidemiology and public health burden of chronic HBV infection, the natural history of chronic HBV infection, and the clinical significance of HBV genotypes and common mutants. The guidelines emphasize the importance of early detection and management to reduce liver-related outcomes and improve patient outcomes.The 2015 Asian-Pacific Clinical Practice Guidelines on the Management of Hepatitis B aim to update the recommendations for the optimal management of chronic hepatitis B virus (HBV) infection. The guidelines, developed by a panel of Asian experts, cover a wide range of care, including new terminology, natural history, screening, vaccination, counseling, diagnosis, assessment of liver disease stage, antiviral treatment, screening for hepatocellular carcinoma (HCC), and management in special situations. The guidelines are based on evidence from existing publications and the experts' personal experience, with recommendations graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Key areas addressed include the epidemiology and public health burden of chronic HBV infection, the natural history of chronic HBV infection, and the clinical significance of HBV genotypes and common mutants. The guidelines emphasize the importance of early detection and management to reduce liver-related outcomes and improve patient outcomes.