This study, published in the *New England Journal of Medicine*, conducted a multicenter, double-blind, placebo-controlled trial to evaluate the effectiveness of low-dose aspirin (150 mg per day) in reducing the risk of preterm preeclampsia in high-risk pregnancies. The trial involved 1776 women with singleton pregnancies who were at high risk for preterm preeclampsia. The primary outcome was delivery with preeclampsia before 37 weeks of gestation. The results showed that preterm preeclampsia occurred in 1.6% of participants in the aspirin group compared to 4.3% in the placebo group, with a significant odds ratio of 0.38 (95% CI 0.20 to 0.74, P=0.004). Adherence to the treatment was good, with 79.9% of participants taking at least 85% of their prescribed tablets. There were no significant differences in the incidence of neonatal adverse outcomes or other adverse events between the groups. The study concluded that low-dose aspirin significantly reduced the incidence of preterm preeclampsia in high-risk pregnancies.This study, published in the *New England Journal of Medicine*, conducted a multicenter, double-blind, placebo-controlled trial to evaluate the effectiveness of low-dose aspirin (150 mg per day) in reducing the risk of preterm preeclampsia in high-risk pregnancies. The trial involved 1776 women with singleton pregnancies who were at high risk for preterm preeclampsia. The primary outcome was delivery with preeclampsia before 37 weeks of gestation. The results showed that preterm preeclampsia occurred in 1.6% of participants in the aspirin group compared to 4.3% in the placebo group, with a significant odds ratio of 0.38 (95% CI 0.20 to 0.74, P=0.004). Adherence to the treatment was good, with 79.9% of participants taking at least 85% of their prescribed tablets. There were no significant differences in the incidence of neonatal adverse outcomes or other adverse events between the groups. The study concluded that low-dose aspirin significantly reduced the incidence of preterm preeclampsia in high-risk pregnancies.