This study investigates the association between exposure to 6PPD-quinone and health outcomes in children, particularly focusing on BMI, influenza, and diarrhea. 6PPD-quinone, a byproduct of tire rubber degradation, has been detected in various environmental media, including dust from e-waste recycling areas. The study collected dust samples from roads, homes, and kindergartens in Guiyu (e-waste exposed) and Haojiang (reference) from 2019 to 2021. Results show that 6PPD-quinone concentrations were significantly higher in the exposed group compared to the reference group, particularly in kindergarten and house dust. Children in the exposed group had a higher daily intake of 6PPD-quinone via ingestion, which was approximately five orders of magnitude higher than inhalation. Exposure to 6PPD-quinone was associated with lower BMI, increased frequency of influenza, and diarrhea in children. The study highlights the potential health risks of 6PPD-quinone exposure, especially in children, and suggests that e-waste recycling areas may be a significant source of this chemical.This study investigates the association between exposure to 6PPD-quinone and health outcomes in children, particularly focusing on BMI, influenza, and diarrhea. 6PPD-quinone, a byproduct of tire rubber degradation, has been detected in various environmental media, including dust from e-waste recycling areas. The study collected dust samples from roads, homes, and kindergartens in Guiyu (e-waste exposed) and Haojiang (reference) from 2019 to 2021. Results show that 6PPD-quinone concentrations were significantly higher in the exposed group compared to the reference group, particularly in kindergarten and house dust. Children in the exposed group had a higher daily intake of 6PPD-quinone via ingestion, which was approximately five orders of magnitude higher than inhalation. Exposure to 6PPD-quinone was associated with lower BMI, increased frequency of influenza, and diarrhea in children. The study highlights the potential health risks of 6PPD-quinone exposure, especially in children, and suggests that e-waste recycling areas may be a significant source of this chemical.