The article reviews the association between insulin resistance and the development of cardiovascular disease (CVD). Insulin resistance, characterized by decreased tissue response to insulin, leads to metabolic alterations that contribute to CVD. These alterations include chronic hyperglycemia, oxidative stress, inflammation, and dyslipidemia. The review highlights the role of insulin signaling in regulating glucose and lipid metabolism, and how insulin resistance impairs these processes. It also discusses the impact of obesity and hyperinsulinemia on insulin resistance, and the subsequent development of CVD. The article further explores the mechanisms by which insulin resistance affects cardiac metabolism, leading to myocardial damage and dysfunction. Finally, it emphasizes the importance of understanding these mechanisms to develop new therapies aimed at reducing insulin resistance and its associated cardiovascular risks.The article reviews the association between insulin resistance and the development of cardiovascular disease (CVD). Insulin resistance, characterized by decreased tissue response to insulin, leads to metabolic alterations that contribute to CVD. These alterations include chronic hyperglycemia, oxidative stress, inflammation, and dyslipidemia. The review highlights the role of insulin signaling in regulating glucose and lipid metabolism, and how insulin resistance impairs these processes. It also discusses the impact of obesity and hyperinsulinemia on insulin resistance, and the subsequent development of CVD. The article further explores the mechanisms by which insulin resistance affects cardiac metabolism, leading to myocardial damage and dysfunction. Finally, it emphasizes the importance of understanding these mechanisms to develop new therapies aimed at reducing insulin resistance and its associated cardiovascular risks.