This study examines the association between cannabis use and cardiovascular outcomes among US adults, focusing on the general population, never-tobacco smokers, and younger individuals. Using data from the Behavioral Risk Factor Surveillance Survey (BRFSS) from 27 states and 2 territories, the researchers analyzed the relationship between cannabis use (number of days of cannabis use in the past 30 days) and self-reported cardiovascular outcomes (coronary heart disease, myocardial infarction, stroke, and a composite measure of all three) in multivariable regression models, adjusting for tobacco use and other characteristics. Key findings include: - Among 434,104 respondents, the prevalence of daily and nondaily cannabis use was 4% and 7.1%, respectively. - Daily cannabis use was associated with increased odds of myocardial infarction (aOR 1.25, 95% CI 1.07–1.46), stroke (aOR 1.42, 95% CI 1.20–1.68), and the composite outcome (aOR 1.28, 95% CI 1.13–1.44). - Among never-tobacco smokers, daily cannabis use was also associated with myocardial infarction (aOR 1.49, 95% CI 1.03–2.15), stroke (aOR 2.16, 95% CI 1.43–3.25), and the composite outcome (aOR 1.77, 95% CI 1.31–2.40). - Relationships between cannabis use and cardiovascular outcomes were similar for men <55 years old and women <65 years old. The study concludes that cannabis use is associated with adverse cardiovascular outcomes, with heavier use (more days per month) associated with higher odds of adverse outcomes. These findings highlight the need for patients and policymakers to be informed about the potential risks of cannabis use, especially given the increasing prevalence of cannabis use and the declining perception of its harmfulness.This study examines the association between cannabis use and cardiovascular outcomes among US adults, focusing on the general population, never-tobacco smokers, and younger individuals. Using data from the Behavioral Risk Factor Surveillance Survey (BRFSS) from 27 states and 2 territories, the researchers analyzed the relationship between cannabis use (number of days of cannabis use in the past 30 days) and self-reported cardiovascular outcomes (coronary heart disease, myocardial infarction, stroke, and a composite measure of all three) in multivariable regression models, adjusting for tobacco use and other characteristics. Key findings include: - Among 434,104 respondents, the prevalence of daily and nondaily cannabis use was 4% and 7.1%, respectively. - Daily cannabis use was associated with increased odds of myocardial infarction (aOR 1.25, 95% CI 1.07–1.46), stroke (aOR 1.42, 95% CI 1.20–1.68), and the composite outcome (aOR 1.28, 95% CI 1.13–1.44). - Among never-tobacco smokers, daily cannabis use was also associated with myocardial infarction (aOR 1.49, 95% CI 1.03–2.15), stroke (aOR 2.16, 95% CI 1.43–3.25), and the composite outcome (aOR 1.77, 95% CI 1.31–2.40). - Relationships between cannabis use and cardiovascular outcomes were similar for men <55 years old and women <65 years old. The study concludes that cannabis use is associated with adverse cardiovascular outcomes, with heavier use (more days per month) associated with higher odds of adverse outcomes. These findings highlight the need for patients and policymakers to be informed about the potential risks of cannabis use, especially given the increasing prevalence of cannabis use and the declining perception of its harmfulness.