This scoping review examines the associations between cancer risk, inflammation, and metabolic syndrome (MetS). The study identified 20 manuscripts that highlighted associations with breast cancer, colorectal cancer, esophageal adenocarcinoma, hepatocellular carcinoma (HCC), and cancer in general. Individuals with MetS exhibit pro-thrombotic and pro-inflammatory conditions, which can lead to cardiovascular disease progression, type 2 diabetes mellitus (T2DM), and certain types of cancer. Chronic inflammation, often associated with age, obesity, and insulin resistance, can contribute to cancer development through various mechanisms, including cellular alteration, proliferation, invasion, angiogenesis, and metastasis. The review also discusses the role of obesity, T2DM, and MetS in cancer risk, emphasizing the importance of dietary prevention and lifestyle modifications in reducing cancer risk. The findings suggest that cancer progression may depend on a latent chronic inflammatory condition associated with other conditions such as T2DM, MetS, and obesity. Therefore, prevention measures may help individuals protect themselves from cancer.This scoping review examines the associations between cancer risk, inflammation, and metabolic syndrome (MetS). The study identified 20 manuscripts that highlighted associations with breast cancer, colorectal cancer, esophageal adenocarcinoma, hepatocellular carcinoma (HCC), and cancer in general. Individuals with MetS exhibit pro-thrombotic and pro-inflammatory conditions, which can lead to cardiovascular disease progression, type 2 diabetes mellitus (T2DM), and certain types of cancer. Chronic inflammation, often associated with age, obesity, and insulin resistance, can contribute to cancer development through various mechanisms, including cellular alteration, proliferation, invasion, angiogenesis, and metastasis. The review also discusses the role of obesity, T2DM, and MetS in cancer risk, emphasizing the importance of dietary prevention and lifestyle modifications in reducing cancer risk. The findings suggest that cancer progression may depend on a latent chronic inflammatory condition associated with other conditions such as T2DM, MetS, and obesity. Therefore, prevention measures may help individuals protect themselves from cancer.