The article discusses the role of astrocytes in selective vulnerability to neurodegenerative disorders. Astrocytes, like neurons, are heterogeneous and specialized, responding to diverse inputs and integrating them into specific functions. In neurodegenerative diseases, such as Alzheimer's, frontotemporal dementia, ALS, Huntington's, and Parkinson's, astrocytes undergo context-dependent changes that promote different pathogenic trajectories and functional outcomes. These changes can be influenced by factors such as aging, neuroinflammation, and protein misfolding. Astrocytes play a crucial role in protein clearance, metabolic regulation, and synaptic function, and their alterations can lead to selective vulnerability in specific brain regions. The article highlights the importance of understanding astrocytic heterogeneity and context-dependent functions in developing therapeutic strategies for neurodegenerative disorders. Further research is needed to elucidate the exact molecular and cellular mechanisms underlying astrocytic changes and their impact on neuronal circuits and brain function.The article discusses the role of astrocytes in selective vulnerability to neurodegenerative disorders. Astrocytes, like neurons, are heterogeneous and specialized, responding to diverse inputs and integrating them into specific functions. In neurodegenerative diseases, such as Alzheimer's, frontotemporal dementia, ALS, Huntington's, and Parkinson's, astrocytes undergo context-dependent changes that promote different pathogenic trajectories and functional outcomes. These changes can be influenced by factors such as aging, neuroinflammation, and protein misfolding. Astrocytes play a crucial role in protein clearance, metabolic regulation, and synaptic function, and their alterations can lead to selective vulnerability in specific brain regions. The article highlights the importance of understanding astrocytic heterogeneity and context-dependent functions in developing therapeutic strategies for neurodegenerative disorders. Further research is needed to elucidate the exact molecular and cellular mechanisms underlying astrocytic changes and their impact on neuronal circuits and brain function.