A survey of 1,000 U.S. adults conducted in April 2020 found that 57.6% intended to be vaccinated against COVID-19, 31.6% were unsure, and 10.8% did not intend to be vaccinated. Factors associated with vaccine hesitancy included younger age, Black race, lower education, and not having received the influenza vaccine. Reasons for hesitancy included concerns about vaccine safety, a need for more information, antivaccine attitudes, and lack of trust. The study highlights the importance of addressing these factors to increase vaccine acceptance. Vaccine hesitancy was particularly high among Black individuals, those with lower education, and those who had not received the influenza vaccine. The findings suggest that targeted efforts are needed to increase vaccine uptake, especially among vulnerable populations. The study also notes that vaccine development is progressing rapidly, with potential availability in 12-18 months. However, vaccine skepticism remains a challenge to widespread acceptance. The study underscores the need for effective communication strategies to address concerns and promote vaccine acceptance.A survey of 1,000 U.S. adults conducted in April 2020 found that 57.6% intended to be vaccinated against COVID-19, 31.6% were unsure, and 10.8% did not intend to be vaccinated. Factors associated with vaccine hesitancy included younger age, Black race, lower education, and not having received the influenza vaccine. Reasons for hesitancy included concerns about vaccine safety, a need for more information, antivaccine attitudes, and lack of trust. The study highlights the importance of addressing these factors to increase vaccine acceptance. Vaccine hesitancy was particularly high among Black individuals, those with lower education, and those who had not received the influenza vaccine. The findings suggest that targeted efforts are needed to increase vaccine uptake, especially among vulnerable populations. The study also notes that vaccine development is progressing rapidly, with potential availability in 12-18 months. However, vaccine skepticism remains a challenge to widespread acceptance. The study underscores the need for effective communication strategies to address concerns and promote vaccine acceptance.