This review article explores the attitudes and barriers towards deprescribing in older patients experiencing polypharmacy. Polypharmacy, defined as the concurrent use of five or more medications, is a growing public health concern due to its associated risks, including adverse drug events, drug interactions, and increased hospital admissions. The review appraises published literature (2012–2022) to identify articles that included new primary data on deprescribing medications in patients aged ≥65 years taking ≥5 medications. Key findings include: - Clinicians generally view deprescribing as a complex process, and while most feel comfortable with it, fewer engage regularly. - Common barriers to deprescribing include lack of knowledge and training, time constraints, communication breakdowns, perceived 'abandonment of care', fear of adverse consequences, and resistance from patients or their carers. - Enabling factors include recognizing opportunities for deprescribing, regular medication reviews, improved communication, patient and clinician education, and a multidisciplinary approach to patient care. The review also discusses the importance of education for both clinicians and patients, maintaining continuity of care, improving communication, and using a multidisciplinary team approach. Future directions emphasize the need for evidence-based guidelines, user-friendly tools, and structured dialogue to facilitate effective deprescribing.This review article explores the attitudes and barriers towards deprescribing in older patients experiencing polypharmacy. Polypharmacy, defined as the concurrent use of five or more medications, is a growing public health concern due to its associated risks, including adverse drug events, drug interactions, and increased hospital admissions. The review appraises published literature (2012–2022) to identify articles that included new primary data on deprescribing medications in patients aged ≥65 years taking ≥5 medications. Key findings include: - Clinicians generally view deprescribing as a complex process, and while most feel comfortable with it, fewer engage regularly. - Common barriers to deprescribing include lack of knowledge and training, time constraints, communication breakdowns, perceived 'abandonment of care', fear of adverse consequences, and resistance from patients or their carers. - Enabling factors include recognizing opportunities for deprescribing, regular medication reviews, improved communication, patient and clinician education, and a multidisciplinary approach to patient care. The review also discusses the importance of education for both clinicians and patients, maintaining continuity of care, improving communication, and using a multidisciplinary team approach. Future directions emphasize the need for evidence-based guidelines, user-friendly tools, and structured dialogue to facilitate effective deprescribing.