This study explores the attitudes and beliefs of African Americans towards participation in medical research. Conducted through focus group interviews with 33 African-American adults at an urban public hospital, the research reveals a significant barrier to participation: mistrust of doctors, scientists, and the government. Participants cited historical examples of exploitation, such as the Tuskegee Syphilis Study, and expressed concerns about the ethical conduct of clinicians and investigators. Many participants misunderstood the concept of informed consent, viewing it as a legal protection for physicians rather than a means to ensure their autonomy. Despite these concerns, participants offered recommendations to improve minority participation in research, emphasizing the need for honest communication, complete information, and trust in researchers. The study highlights the importance of addressing mistrust and enhancing communication to increase African American participation in clinical trials.This study explores the attitudes and beliefs of African Americans towards participation in medical research. Conducted through focus group interviews with 33 African-American adults at an urban public hospital, the research reveals a significant barrier to participation: mistrust of doctors, scientists, and the government. Participants cited historical examples of exploitation, such as the Tuskegee Syphilis Study, and expressed concerns about the ethical conduct of clinicians and investigators. Many participants misunderstood the concept of informed consent, viewing it as a legal protection for physicians rather than a means to ensure their autonomy. Despite these concerns, participants offered recommendations to improve minority participation in research, emphasizing the need for honest communication, complete information, and trust in researchers. The study highlights the importance of addressing mistrust and enhancing communication to increase African American participation in clinical trials.