This study investigates the relationship between autoantibodies to oxidized low-density lipoprotein (LDL) and the progression of carotid atherosclerosis in Finnish men. The researchers compared baseline serum samples from 30 men with accelerated carotid atherosclerosis over two years and 30 age-matched controls. They found that the titre of autoantibodies to malondialdehyde (MDA)-lysine, a prominent epitope of oxidized LDL, was significantly higher in cases compared to controls (2.67 vs 2.06, p=0.003). After adjusting for variables such as smoking, LDL cholesterol, and serum copper concentration, the difference in antibody titre remained significant (p=0.031). The results suggest that autoantibodies to MDA-LDL are an independent predictor of carotid atherosclerosis progression, supporting the role of oxidized LDL in atherogenesis.This study investigates the relationship between autoantibodies to oxidized low-density lipoprotein (LDL) and the progression of carotid atherosclerosis in Finnish men. The researchers compared baseline serum samples from 30 men with accelerated carotid atherosclerosis over two years and 30 age-matched controls. They found that the titre of autoantibodies to malondialdehyde (MDA)-lysine, a prominent epitope of oxidized LDL, was significantly higher in cases compared to controls (2.67 vs 2.06, p=0.003). After adjusting for variables such as smoking, LDL cholesterol, and serum copper concentration, the difference in antibody titre remained significant (p=0.031). The results suggest that autoantibodies to MDA-LDL are an independent predictor of carotid atherosclerosis progression, supporting the role of oxidized LDL in atherogenesis.