From March 16 to June 14, 2024, 42 highly pathogenic avian influenza (HPAI) A(H5) virus detections were reported in domestic and wild birds across 13 European countries. While the overall number of detections is the lowest since the 2019-2020 epidemiological year, HPAI viruses continue to circulate at a very low level. Most detections in poultry were due to indirect contact with wild birds, but there was also secondary spread. Outside Europe, the situation intensified particularly in the USA, where a new A(H5N1) virus genotype (B3.13) was identified in over 130 dairy herds in 12 states. Infection in cattle appears to be centered on the udder, with milk from infected animals showing high viral loads and representing a new vehicle of transmission. HPAI viruses were also detected in two other mammal species (alpaca and walrus) for the first time. Between March 13 and June 20, 2024, 14 new human cases with avian influenza virus infection were reported from Vietnam, Australia, the USA, China, India, and Mexico. Most of the human cases had reported exposure to poultry, live poultry markets, or dairy cattle prior to detection or onset of illness. Human infections with avian influenza viruses remain rare, and no human-to-human transmission has been observed. The risk of infection with currently circulating avian A(H5) influenza viruses of clade 2.3.4.4b in Europe remains low for the general public in the EU/EEA. The risk of infection remains low-to-moderate for those occupationally or otherwise exposed to infected animals or contaminated environments.From March 16 to June 14, 2024, 42 highly pathogenic avian influenza (HPAI) A(H5) virus detections were reported in domestic and wild birds across 13 European countries. While the overall number of detections is the lowest since the 2019-2020 epidemiological year, HPAI viruses continue to circulate at a very low level. Most detections in poultry were due to indirect contact with wild birds, but there was also secondary spread. Outside Europe, the situation intensified particularly in the USA, where a new A(H5N1) virus genotype (B3.13) was identified in over 130 dairy herds in 12 states. Infection in cattle appears to be centered on the udder, with milk from infected animals showing high viral loads and representing a new vehicle of transmission. HPAI viruses were also detected in two other mammal species (alpaca and walrus) for the first time. Between March 13 and June 20, 2024, 14 new human cases with avian influenza virus infection were reported from Vietnam, Australia, the USA, China, India, and Mexico. Most of the human cases had reported exposure to poultry, live poultry markets, or dairy cattle prior to detection or onset of illness. Human infections with avian influenza viruses remain rare, and no human-to-human transmission has been observed. The risk of infection with currently circulating avian A(H5) influenza viruses of clade 2.3.4.4b in Europe remains low for the general public in the EU/EEA. The risk of infection remains low-to-moderate for those occupationally or otherwise exposed to infected animals or contaminated environments.