This study investigates the crashworthiness of 3D-printed gyroid structure tubes with circular holes, aiming to reduce the risk and severity of injuries during collisions. The research focuses on optimizing the design parameters—hole diameter ($d$), number of holes ($n$), and their positions ($L$)—using the Taguchi technique within a design of experiments (DOE) approach. The optimal parameters were determined based on the lowest initial peak crash force ($F_{\text{ip}}$) and the largest absorbed energy ($U$). The analysis revealed that the position of the holes ($L$) has the most significant impact on $F_{\text{ip}}$ (66.35% influence), while the hole diameter ($d$) has the most significant influence on $U$ (41.22% contribution). A confirmation test validated the predicted values, showing that the designed tubes had a 30.48% reduction in $F_{\text{ip}}$ and a 17.21% increase in $U$ compared to intact tubes. The study highlights the significant influence of holes on the crashworthiness performance of 3D-printed tubes, emphasizing the importance of optimizing these parameters for improved vehicle safety.This study investigates the crashworthiness of 3D-printed gyroid structure tubes with circular holes, aiming to reduce the risk and severity of injuries during collisions. The research focuses on optimizing the design parameters—hole diameter ($d$), number of holes ($n$), and their positions ($L$)—using the Taguchi technique within a design of experiments (DOE) approach. The optimal parameters were determined based on the lowest initial peak crash force ($F_{\text{ip}}$) and the largest absorbed energy ($U$). The analysis revealed that the position of the holes ($L$) has the most significant impact on $F_{\text{ip}}$ (66.35% influence), while the hole diameter ($d$) has the most significant influence on $U$ (41.22% contribution). A confirmation test validated the predicted values, showing that the designed tubes had a 30.48% reduction in $F_{\text{ip}}$ and a 17.21% increase in $U$ compared to intact tubes. The study highlights the significant influence of holes on the crashworthiness performance of 3D-printed tubes, emphasizing the importance of optimizing these parameters for improved vehicle safety.